Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy
Copyright © 2023. Published by Elsevier Inc..
Diabetic nephropathy (DN) is an important complication of diabetes and is the main cause of end-stage renal disease. The pathogenesis of DN is complex, including glucose and lipid metabolism disorder, inflammation, and so on. Novel hybrid micelles loaded Puerarin (Pue) based on Angelica sinensis polysaccharides (ASP) and Astragalus polysaccharide (APS) were fabricated with pH-responsive ASP-hydrazone-ibuprofen (BF) materials (ASP-HZ-BF, SHB) and sialic acid (SA) modified APS-hydrazone-ibuprofen materials (SA/APS-HZ-BF, SPHB) by thin-film dispersion method. The SA in hybrid micelles can specifically bind to the E-selectin receptor which is highly expressed in inflammatory vascular endothelial cells. The loaded Pue could be accurately delivered to the inflammatory site of the kidney in response to the low pH microenvironment. Overall, this study provides a promising strategy for developing hybrid micelles based on natural polysaccharides for the treatment of diabetic nephropathy by inhibiting renal inflammatory reactions, and antioxidant stress.
| Media Type: |
Electronic Article |
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| Year of Publication: |
2023 |
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| Publication: |
2023 |
| Contained In: |
To Main Record - volume:52 |
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| Contained In: |
Nanomedicine : nanotechnology, biology, and medicine - 52(2023) vom: 15. Aug., Seite 102696 |
| Language: |
English |
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| Contributors: |
Guo, Chunjing [Author] |
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| Links: |
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| Keywords: |
Angelica sinensis polysaccharides |
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| Notes: |
Date Completed 01.09.2023 Date Revised 01.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.nano.2023.102696 |
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| funding: |
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| Supporting institution / Project title: |
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| 520 | |a Diabetic nephropathy (DN) is an important complication of diabetes and is the main cause of end-stage renal disease. The pathogenesis of DN is complex, including glucose and lipid metabolism disorder, inflammation, and so on. Novel hybrid micelles loaded Puerarin (Pue) based on Angelica sinensis polysaccharides (ASP) and Astragalus polysaccharide (APS) were fabricated with pH-responsive ASP-hydrazone-ibuprofen (BF) materials (ASP-HZ-BF, SHB) and sialic acid (SA) modified APS-hydrazone-ibuprofen materials (SA/APS-HZ-BF, SPHB) by thin-film dispersion method. The SA in hybrid micelles can specifically bind to the E-selectin receptor which is highly expressed in inflammatory vascular endothelial cells. The loaded Pue could be accurately delivered to the inflammatory site of the kidney in response to the low pH microenvironment. Overall, this study provides a promising strategy for developing hybrid micelles based on natural polysaccharides for the treatment of diabetic nephropathy by inhibiting renal inflammatory reactions, and antioxidant stress | ||
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| 700 | 1 | |a Chen, Daquan |e verfasserin |4 aut | |
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