PNA-ATP aptamer-capped doxorubicin-loaded silica nanoparticles for targeted cancer therapy

Copyright © 2022 Elsevier Inc. All rights reserved..

Nanomaterial-based drug delivery has opened new horizons in cancer therapy. This study aimed to investigate the in vitro and in vivo anti-cancer effects of a hyaluronic acid (HA)-targeted nanocarrier based on hollow silica nanoparticles (HSNPs), gated with peptide nucleic acid (PNA) and ATP aptamer (ATPApt) and loaded with doxorubicin (DOX). After formulation of a smart drug delivery nanosystem (HSNPs/DOX/ATPApt/PNA/HA), drug release, cytotoxicity, uptake, and in vivo anti-tumor properties were studied. Drug release test showed the controlled release of encapsulated DOX in response to ATP content. MTT and flow cytometry indicated that HA could improve both cytotoxicity and cellular uptake of the formulation. Moreover, HA-targeted formulation enhanced both the survival rate and tumor inhibition in the tumor-bearing mice compared with free DOX (P < 0.05). Our findings confirmed that HA-targeted nanoformulation, gated with PNA/aptamer and loaded with DOX can provide a novel therapeutic platform with great potential for cancer therapy.

Media Type:

Electronic Article

Year of Publication:

2022

Publication:

2022

Contained In:

To Main Record - volume:45

Contained In:

Nanomedicine : nanotechnology, biology, and medicine - 45(2022) vom: 26. Sept., Seite 102588

Language:

English

Contributors:

Kazemi, Youkabed [Author]
Dehghani, Sadegh [Author]
Soltani, Fatemeh [Author]
Abnous, Khalil [Author]
Alibolandi, Mona [Author]
Taghdisi, Seyed Mohammad [Author]
Ramezani, Mohammad [Author]

Links:

Volltext

Keywords:

7320-57-2
7631-86-9
80168379AG
8L70Q75FXE
9004-61-9
APT
Adenosine Triphosphate
Aptamer
Delayed-Action Preparations
Dimaprit
Doxorubicin
Drug delivery
Hyaluronic Acid
Hyaluronic acid
Journal Article
Peptide Nucleic Acids
Research Support, Non-U.S. Gov't
Silica nanoparticle
Silicon Dioxide
ZZQ699148P

Notes:

Date Completed 23.09.2022

Date Revised 25.10.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.nano.2022.102588

funding:

Supporting institution / Project title:

PPN (Catalogue-ID):

NLM34419860X