Dietary iron and zinc intakes and nonalcoholic fatty liver disease : A meta-analysis
BACKGROUND AND OBJECTIVES: The differences of dietary iron and zinc intakes between patients with nonalcoholic fatty liver disease (NAFLD) and controls remain controversial. The meta-analysis aimed to explore the differences of dietary iron and zinc intakes between NAFLD patients and healthy subjects.
METHODS AND STUDY DESIGN: A systematic literature search was performed up to July 2021 in databases of PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Using a randomeffects model, the differences of dietary iron and zinc intakes between cases and controls were calculated as standardized mean differences (SMDs) with 95% confidence intervals (CIs). A total of 21 studies from 19 articles with 6639 cases were included.
RESULTS: The pooled estimate showed no difference in dietary iron consumption in the NAFLD groups compared with control groups. The difference became significant in Asia (SMD=0.16; 95% CI: 0.04, 0.28; I2=89.1%; pheterogeneity<0.001) as well as in cross-sectional studies (SMD=0.12; 95% CI: 0.07, 0.17; I2=4.7%; pheterogeneity=0.350). The difference in dietary zinc intake between cases and controls was not significant. We noticed a statistically significant increase of dietary zinc intake in NAFLD compared to controls in studies using food-frequency questionnaire (FFQ) to evaluate dietary intake (SMD=0.15; 95% CI: 0.10, 0.20; I2=12.2%; pheterogeneity=0.332).
CONCLUSIONS: Our findings indicated that dietary iron intake in patients with NAFLD was higher than healthy subjects in Asia.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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Enthalten in: |
Asia Pacific journal of clinical nutrition - 30(2021), 4 vom: 22. Dez., Seite 704-714 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Li, Jing [VerfasserIn] |
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Anmerkungen: |
Date Completed 31.12.2021 Date Revised 31.12.2021 published: Print Citation Status MEDLINE |
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doi: |
10.6133/apjcn.202112_30(4).0017 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM335030084 |
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520 | |a BACKGROUND AND OBJECTIVES: The differences of dietary iron and zinc intakes between patients with nonalcoholic fatty liver disease (NAFLD) and controls remain controversial. The meta-analysis aimed to explore the differences of dietary iron and zinc intakes between NAFLD patients and healthy subjects | ||
520 | |a METHODS AND STUDY DESIGN: A systematic literature search was performed up to July 2021 in databases of PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Using a randomeffects model, the differences of dietary iron and zinc intakes between cases and controls were calculated as standardized mean differences (SMDs) with 95% confidence intervals (CIs). A total of 21 studies from 19 articles with 6639 cases were included | ||
520 | |a RESULTS: The pooled estimate showed no difference in dietary iron consumption in the NAFLD groups compared with control groups. The difference became significant in Asia (SMD=0.16; 95% CI: 0.04, 0.28; I2=89.1%; pheterogeneity<0.001) as well as in cross-sectional studies (SMD=0.12; 95% CI: 0.07, 0.17; I2=4.7%; pheterogeneity=0.350). The difference in dietary zinc intake between cases and controls was not significant. We noticed a statistically significant increase of dietary zinc intake in NAFLD compared to controls in studies using food-frequency questionnaire (FFQ) to evaluate dietary intake (SMD=0.15; 95% CI: 0.10, 0.20; I2=12.2%; pheterogeneity=0.332) | ||
520 | |a CONCLUSIONS: Our findings indicated that dietary iron intake in patients with NAFLD was higher than healthy subjects in Asia | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Meta-Analysis | |
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700 | 1 | |a Yang, Jieyong |e verfasserin |4 aut | |
700 | 1 | |a Cui, Jiajia |e verfasserin |4 aut | |
700 | 1 | |a Sun, Yongye |e verfasserin |4 aut | |
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