Dietary iron and zinc intakes and nonalcoholic fatty liver disease : A meta-analysis

BACKGROUND AND OBJECTIVES: The differences of dietary iron and zinc intakes between patients with nonalcoholic fatty liver disease (NAFLD) and controls remain controversial. The meta-analysis aimed to explore the differences of dietary iron and zinc intakes between NAFLD patients and healthy subjects.

METHODS AND STUDY DESIGN: A systematic literature search was performed up to July 2021 in databases of PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Using a randomeffects model, the differences of dietary iron and zinc intakes between cases and controls were calculated as standardized mean differences (SMDs) with 95% confidence intervals (CIs). A total of 21 studies from 19 articles with 6639 cases were included.

RESULTS: The pooled estimate showed no difference in dietary iron consumption in the NAFLD groups compared with control groups. The difference became significant in Asia (SMD=0.16; 95% CI: 0.04, 0.28; I2=89.1%; pheterogeneity<0.001) as well as in cross-sectional studies (SMD=0.12; 95% CI: 0.07, 0.17; I2=4.7%; pheterogeneity=0.350). The difference in dietary zinc intake between cases and controls was not significant. We noticed a statistically significant increase of dietary zinc intake in NAFLD compared to controls in studies using food-frequency questionnaire (FFQ) to evaluate dietary intake (SMD=0.15; 95% CI: 0.10, 0.20; I2=12.2%; pheterogeneity=0.332).

CONCLUSIONS: Our findings indicated that dietary iron intake in patients with NAFLD was higher than healthy subjects in Asia.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:30

Enthalten in:

Asia Pacific journal of clinical nutrition - 30(2021), 4 vom: 22. Dez., Seite 704-714

Sprache:

Englisch

Beteiligte Personen:

Li, Jing [VerfasserIn]
Yu, Jinran [VerfasserIn]
Yang, Jieyong [VerfasserIn]
Cui, Jiajia [VerfasserIn]
Sun, Yongye [VerfasserIn]

Links:

Volltext

Themen:

Iron, Dietary
J41CSQ7QDS
Journal Article
Meta-Analysis
Zinc

Anmerkungen:

Date Completed 31.12.2021

Date Revised 31.12.2021

published: Print

Citation Status MEDLINE

doi:

10.6133/apjcn.202112_30(4).0017

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM335030084