An Overview of Zebrafish Modeling Methods in Drug Discovery and Development

© 2021. Springer Nature Switzerland AG..

Animal studies are recognized as a significant step forward in the bridging between drug discovery and clinical applications. Animal models, due to their relative genetic, molecular, physiological, and even anatomical similarities to humans, can provide a suitable platform for unraveling the mechanisms underlying human diseases and discovering new therapeutic approaches as well. Recently, zebrafish has attracted attention as a valuable experimental and pharmacological model in drug discovery and development studies due to its prominent characteristics such as the high degree of genetic similarity with humans, genetic manipulability, and prominent clinical features. Since advancing a theory to a valid and reliable observation requires the manipulation of animals, it is, therefore, essential to use efficient modeling methods appropriate to the different aspects of experimental conditions. In this context, applying several various approaches such as using chemicals, pathogens, and genetic manipulation approaches allows zebrafish development into a preferable model that mimics some human disease pathophysiology. Thus, such modeling approaches not only can provide a framework for a comprehensive understanding of the human disease mechanisms that have a counterpart in zebrafish but also can pave the way for discovering new drugs that are accompanied by higher amelioration effects on different human diseases.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:1387

Enthalten in:

Advances in experimental medicine and biology - 1387(2022) vom: 27., Seite 145-169

Sprache:

Englisch

Beteiligte Personen:

Larijani, Bagher [VerfasserIn]
Hamidpour, Shayesteh Kokabi [VerfasserIn]
Tayanloo-Beik, Akram [VerfasserIn]
Shahbazbadr, Ainaz [VerfasserIn]
Yavari, Hanieh [VerfasserIn]
Namazi, Nazli [VerfasserIn]
Biglar, Mahmood [VerfasserIn]
Arjmand, Babak [VerfasserIn]

Links:

Volltext

Themen:

Animal modeling
Danio rerio
Drug development
Drug discovery
In vivo studies
Journal Article
Zebrafish

Anmerkungen:

Date Completed 01.08.2022

Date Revised 01.08.2022

published: Print

Citation Status MEDLINE

doi:

10.1007/5584_2021_684

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM334977657