Evidence of SARS-CoV-2-Specific T-Cell-Mediated Myocarditis in a MIS-A Case
Copyright © 2021 Vannella, Oguz, Stein, Pittaluga, Dikoglu, Kanwal, Ramelli, Briese, Su, Wu, Ramos-Benitez, Perez-Valencia, Babyak, Cha, Chung, Ylaya, Madathil, Saharia, Scalea, Tran, Herr, Kleiner, Hewitt, Notarangelo, Grazioli and Chertow..
A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Frontiers in immunology - 12(2021) vom: 20., Seite 779026 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vannella, Kevin M [VerfasserIn] |
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| Links: |
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| Themen: |
CDR3 sequences |
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| Anmerkungen: |
Date Completed 06.01.2022 Date Revised 06.01.2022 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2021.779026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a A 26-year-old otherwise healthy man died of fulminant myocarditis. Nasopharyngeal specimens collected premortem tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Histopathological evaluation of the heart showed myocardial necrosis surrounded by cytotoxic T-cells and tissue-repair macrophages. Myocardial T-cell receptor (TCR) sequencing revealed hyper-dominant clones with highly similar sequences to TCRs that are specific for SARS-CoV-2 epitopes. SARS-CoV-2 RNA was detected in the gut, supporting a diagnosis of multisystem inflammatory syndrome in adults (MIS-A). Molecular targets of MIS-associated inflammation are not known. Our data indicate that SARS-CoV-2 antigens selected high-frequency T-cell clones that mediated fatal myocarditis | ||
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| 700 | 1 | |a Stein, Sydney R |e verfasserin |4 aut | |
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| 700 | 1 | |a Dikoglu, Esra |e verfasserin |4 aut | |
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| 700 | 1 | |a Su, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xiaolin |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos-Benitez, Marcos J |e verfasserin |4 aut | |
| 700 | 1 | |a Perez-Valencia, Luis J |e verfasserin |4 aut | |
| 700 | 1 | |a Babyak, Ashley |e verfasserin |4 aut | |
| 700 | 1 | |a Cha, Nu Ri |e verfasserin |4 aut | |
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| 700 | 1 | |a Ylaya, Kris |e verfasserin |4 aut | |
| 700 | 1 | |a Madathil, Ronson J |e verfasserin |4 aut | |
| 700 | 1 | |a Saharia, Kapil K |e verfasserin |4 aut | |
| 700 | 1 | |a Scalea, Thomas M |e verfasserin |4 aut | |
| 700 | 1 | |a Tran, Quincy K |e verfasserin |4 aut | |
| 700 | 1 | |a Herr, Daniel L |e verfasserin |4 aut | |
| 700 | 1 | |a Kleiner, David E |e verfasserin |4 aut | |
| 700 | 1 | |a Hewitt, Stephen M |e verfasserin |4 aut | |
| 700 | 1 | |a Notarangelo, Luigi D |e verfasserin |4 aut | |
| 700 | 1 | |a Grazioli, Alison |e verfasserin |4 aut | |
| 700 | 1 | |a Chertow, Daniel S |e verfasserin |4 aut | |
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