Frequency and genotype distribution of hepatitis C virus infection in patients with diabetes type 2 in Ahvaz, Iran
Copyright © 2021 The Authors. Published by Tehran University of Medical Sciences..
BACKGROUND AND OBJECTIVES: Diabetes is recognized as a great concern and a public health problem worldwide. Several factors including environmental and genetic factors have been involved. Recently, infectious agents such as hepatitis C virus (HCV) have been reported to be associated with diabetes. Thus, this study was conducted to determine the frequency of HCV infection among patients with diabetes type 2 in Ahvaz city, Iran.
MATERIALS AND METHODS: A case-control study design was conducted at Ahvaz Jundishapur University of Medical Sciences. A total of 600 study subjects were included in this research. All the patient sera were tested for Anti-HCV antibody, HBsAg, and HIV antibody. The sera of positive Anti-HCV antibody, were assayed for 5'- UTR and core regions of the HCV genome by Nested RT-PCR. Finally, the HCV genotyping was determined by sequencing.
RESULTS: The prevalence of HCV in type 2 diabetes and nondiabetic controls was 2% and 0.33%, respectively. The distribution of HCV genotypes among the HCV-positive patients were 3a (1.66%) and 1a (0.33%).
CONCLUSION: To control and improve the treatment, the screening of HCV infection with anti-HCV antibody was followed by molecular techniques such as PCR and HCV genotyping which should be implemented for all patients with diabetes type 2.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Iranian journal of microbiology - 13(2021), 5 vom: 03. Okt., Seite 703-711 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Makvandi, Manoochehr [VerfasserIn] |
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| Links: |
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| Themen: |
Diabetes mellitus type 2 |
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| Anmerkungen: |
Date Revised 29.04.2022 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.18502/ijm.v13i5.7437 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM334366402 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2021 The Authors. Published by Tehran University of Medical Sciences. | ||
| 520 | |a BACKGROUND AND OBJECTIVES: Diabetes is recognized as a great concern and a public health problem worldwide. Several factors including environmental and genetic factors have been involved. Recently, infectious agents such as hepatitis C virus (HCV) have been reported to be associated with diabetes. Thus, this study was conducted to determine the frequency of HCV infection among patients with diabetes type 2 in Ahvaz city, Iran | ||
| 520 | |a MATERIALS AND METHODS: A case-control study design was conducted at Ahvaz Jundishapur University of Medical Sciences. A total of 600 study subjects were included in this research. All the patient sera were tested for Anti-HCV antibody, HBsAg, and HIV antibody. The sera of positive Anti-HCV antibody, were assayed for 5'- UTR and core regions of the HCV genome by Nested RT-PCR. Finally, the HCV genotyping was determined by sequencing | ||
| 520 | |a RESULTS: The prevalence of HCV in type 2 diabetes and nondiabetic controls was 2% and 0.33%, respectively. The distribution of HCV genotypes among the HCV-positive patients were 3a (1.66%) and 1a (0.33%) | ||
| 520 | |a CONCLUSION: To control and improve the treatment, the screening of HCV infection with anti-HCV antibody was followed by molecular techniques such as PCR and HCV genotyping which should be implemented for all patients with diabetes type 2 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Diabetes mellitus type 2 | |
| 650 | 4 | |a Genotype | |
| 650 | 4 | |a HCV | |
| 650 | 4 | |a Prevalence | |
| 700 | 1 | |a Azaran, Azarakhsh |e verfasserin |4 aut | |
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| 700 | 1 | |a Nahad, Mehdi Parsa |e verfasserin |4 aut | |
| 700 | 1 | |a Azizolahi, Behnam |e verfasserin |4 aut | |
| 700 | 1 | |a Neisi, Niloofar |e verfasserin |4 aut | |
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