Planar photonic chips with tailored angular transmission for high-contrast-imaging devices

© 2021. The Author(s)..

A limitation of standard brightfield microscopy is its low contrast images, especially for thin specimens of weak absorption, and biological species with refractive indices very close in value to that of their surroundings. We demonstrate, using a planar photonic chip with tailored angular transmission as the sample substrate, a standard brightfield microscopy can provide both darkfield and total internal reflection (TIR) microscopy images with one experimental configuration. The image contrast is enhanced without altering the specimens and the microscope configurations. This planar chip consists of several multilayer sections with designed photonic band gaps and a central region with dielectric nanoparticles, which does not require top-down nanofabrication and can be fabricated in a larger scale. The photonic chip eliminates the need for a bulky condenser or special objective to realize darkfield or TIR illumination. Thus, it can work as a miniaturized high-contrast-imaging device for the developments of versatile and compact microscopes.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:12

Enthalten in:

Nature communications - 12(2021), 1 vom: 25. Nov., Seite 6835

Sprache:

Englisch

Beteiligte Personen:

Kuai, Yan [VerfasserIn]
Chen, Junxue [VerfasserIn]
Fan, Zetao [VerfasserIn]
Zou, Gang [VerfasserIn]
Lakowicz, Joseph R [VerfasserIn]
Zhang, Douguo [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 30.12.2021

Date Revised 30.12.2021

published: Electronic

figshare: 10.6084/m9.figshare.16842913

Citation Status MEDLINE

doi:

10.1038/s41467-021-27231-6

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM333614151