Brain-derived estrogen and neural function
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved..
Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different species. In this review, we provide a comprehensive overview of the localization, regulation, sex differences, and physiological/pathological roles of brain-derived E2 (BDE2). Much of what we know regarding the functional roles of BDE2 has come from studies using specific inhibitors of the E2 synthesis enzyme, aromatase, as well as the recent development of conditional forebrain neuron-specific and astrocyte-specific aromatase knockout mouse models. The evidence from these studies support a critical role for neuron-derived E2 (NDE2) in the regulation of synaptic plasticity, memory, socio-sexual behavior, sexual differentiation, reproduction, injury-induced reactive gliosis, and neuroprotection. Furthermore, we review evidence that astrocyte-derived E2 (ADE2) is induced following brain injury/ischemia, and plays a key role in reactive gliosis, neuroprotection, and cognitive preservation. Finally, we conclude by discussing the key controversies and challenges in this area, as well as potential future directions for the field.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:132 |
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Enthalten in: |
Neuroscience and biobehavioral reviews - 132(2022) vom: 05. Jan., Seite 793-817 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Brann, Darrell W [VerfasserIn] |
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Links: |
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Themen: |
17β-Estradiol |
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Anmerkungen: |
Date Completed 01.03.2022 Date Revised 01.03.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.neubiorev.2021.11.014 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM333610709 |
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520 | |a Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
520 | |a Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different species. In this review, we provide a comprehensive overview of the localization, regulation, sex differences, and physiological/pathological roles of brain-derived E2 (BDE2). Much of what we know regarding the functional roles of BDE2 has come from studies using specific inhibitors of the E2 synthesis enzyme, aromatase, as well as the recent development of conditional forebrain neuron-specific and astrocyte-specific aromatase knockout mouse models. The evidence from these studies support a critical role for neuron-derived E2 (NDE2) in the regulation of synaptic plasticity, memory, socio-sexual behavior, sexual differentiation, reproduction, injury-induced reactive gliosis, and neuroprotection. Furthermore, we review evidence that astrocyte-derived E2 (ADE2) is induced following brain injury/ischemia, and plays a key role in reactive gliosis, neuroprotection, and cognitive preservation. Finally, we conclude by discussing the key controversies and challenges in this area, as well as potential future directions for the field | ||
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700 | 1 | |a Wang, Jing |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Quanguang |e verfasserin |4 aut | |
700 | 1 | |a Thakkar, Roshni |e verfasserin |4 aut | |
700 | 1 | |a Sareddy, Gangadhara R |e verfasserin |4 aut | |
700 | 1 | |a Pratap, Uday P |e verfasserin |4 aut | |
700 | 1 | |a Tekmal, Rajeshwar R |e verfasserin |4 aut | |
700 | 1 | |a Vadlamudi, Ratna K |e verfasserin |4 aut | |
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