Brain-derived estrogen and neural function

Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved..

Although classically known as an endocrine signal produced by the ovary, 17β-estradiol (E2) is also a neurosteroid produced in neurons and astrocytes in the brain of many different species. In this review, we provide a comprehensive overview of the localization, regulation, sex differences, and physiological/pathological roles of brain-derived E2 (BDE2). Much of what we know regarding the functional roles of BDE2 has come from studies using specific inhibitors of the E2 synthesis enzyme, aromatase, as well as the recent development of conditional forebrain neuron-specific and astrocyte-specific aromatase knockout mouse models. The evidence from these studies support a critical role for neuron-derived E2 (NDE2) in the regulation of synaptic plasticity, memory, socio-sexual behavior, sexual differentiation, reproduction, injury-induced reactive gliosis, and neuroprotection. Furthermore, we review evidence that astrocyte-derived E2 (ADE2) is induced following brain injury/ischemia, and plays a key role in reactive gliosis, neuroprotection, and cognitive preservation. Finally, we conclude by discussing the key controversies and challenges in this area, as well as potential future directions for the field.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:132

Enthalten in:

Neuroscience and biobehavioral reviews - 132(2022) vom: 05. Jan., Seite 793-817

Sprache:

Englisch

Beteiligte Personen:

Brann, Darrell W [VerfasserIn]
Lu, Yujiao [VerfasserIn]
Wang, Jing [VerfasserIn]
Zhang, Quanguang [VerfasserIn]
Thakkar, Roshni [VerfasserIn]
Sareddy, Gangadhara R [VerfasserIn]
Pratap, Uday P [VerfasserIn]
Tekmal, Rajeshwar R [VerfasserIn]
Vadlamudi, Ratna K [VerfasserIn]

Links:

Volltext

Themen:

17β-Estradiol
4TI98Z838E
Aromatase
Estradiol
Estrogens
Gliosis
Journal Article
Memory
Neuroprotection
Neurosteroid
Research Support, Non-U.S. Gov't
Review
Sexual behavior
Synaptic plasticity

Anmerkungen:

Date Completed 01.03.2022

Date Revised 01.03.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.neubiorev.2021.11.014

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM333610709