An Approach to the Synthesis of Electron-Rich and Hindered Esters and Its Application to the Synthesis of Acteoside
Electron-rich esters are ubiquitously distributed in natural products and play a central role in bioactivities. Herein, we disclose an efficient, mild, and general esterification approach to the synthesis of these esters by employing gold(I)-catalyzed acylation reaction with alkyne-tethered mixed anhydrides and alcohols. This method can be applied to ester-bond formation in complex substrates and facilitates efficient synthesis of acteoside, which belongs to the family of phenylethanoid glycosides and possesses a broad range of bioactivities.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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Enthalten in: |
Organic letters - 23(2021), 23 vom: 03. Dez., Seite 9210-9215 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Zhang, Xiaojuan [VerfasserIn] |
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Links: |
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Themen: |
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Anmerkungen: |
Date Completed 08.02.2022 Date Revised 08.02.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.1021/acs.orglett.1c03528 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM333173937 |
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520 | |a Electron-rich esters are ubiquitously distributed in natural products and play a central role in bioactivities. Herein, we disclose an efficient, mild, and general esterification approach to the synthesis of these esters by employing gold(I)-catalyzed acylation reaction with alkyne-tethered mixed anhydrides and alcohols. This method can be applied to ester-bond formation in complex substrates and facilitates efficient synthesis of acteoside, which belongs to the family of phenylethanoid glycosides and possesses a broad range of bioactivities | ||
650 | 4 | |a Journal Article | |
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700 | 1 | |a Wang, Fuye |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Zhengbing |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Hongbin |e verfasserin |4 aut | |
700 | 1 | |a Zhu, Yugen |e verfasserin |4 aut | |
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