Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
© 2021. The Author(s)..
BACKGROUND: Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility.
METHODS: We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES.
RESULTS: The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES.
CONCLUSION: A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
BMC complementary medicine and therapies - 21(2021), 1 vom: 04. Nov., Seite 275 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tey, Shu-Leei [VerfasserIn] |
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| Links: |
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| Themen: |
Arecae pericarpium |
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| Anmerkungen: |
Date Completed 14.12.2021 Date Revised 14.12.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12906-021-03442-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332745406 |
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| 245 | 1 | 0 | |a Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors |
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| 500 | |a Date Completed 14.12.2021 | ||
| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a BACKGROUND: Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility | ||
| 520 | |a METHODS: We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES | ||
| 520 | |a RESULTS: The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES | ||
| 520 | |a CONCLUSION: A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Arecae pericarpium | |
| 650 | 4 | |a Lower esophageal sphincter | |
| 650 | 4 | |a Motility | |
| 650 | 4 | |a Muscarinic receptor | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 650 | 7 | |a Receptors, Muscarinic |2 NLM | |
| 700 | 1 | |a Li, Chi-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Li-Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Li-Ching |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yea-Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Fang-Rong |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, San-Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Ching-Chung |e verfasserin |4 aut | |
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