Podocyte Aging : Why and How Getting Old Matters
Copyright © 2021 by the American Society of Nephrology..
The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population's increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Journal of the American Society of Nephrology : JASN - 32(2021), 11 vom: 01. Nov., Seite 2697-2713 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shankland, Stuart J [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.12.2021 Date Revised 14.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1681/ASN.2021050614 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population's increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents | ||
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