Secondary organizing pneumonia after recovery of mild COVID-19 infection

© 2021 Wiley Periodicals LLC..

A 36-year-old male with diffuse large B-cell lymphoma on maintenance rituximab therapy presented to the emergency department with high fever and fatigue. A chest X-ray showed a lobar infiltrate, 40 days before admission the patient suffered from a mild coronavirus disease 2019 (COVID-19) infection and fully recovered. PCR nasopharyngeal swab was negative for COVID-19. Comprehensive biochemical, radiological, and pathological evaluation including 18-fluorodeoxyglucose positron emission tomography with computed tomography and transbronchial lung biopsy found no pathogen or lymphoma recurrence. Treatment for pneumonia with antibiotic and antifungal agents was nonbeneficial. A diagnosis of secondary organizing pneumonia (OP) was made after pneumonia migration and a rapid response to corticosteroids. OP secondary to a viral respiratory infection has been well described. Raising awareness for post-COVID-19 OP has therapeutic and prognostic importance because those patients benefit from steroid therapy. We believe the condition described here is underdiagnosed and undertreated by doctors worldwide. Because of the ongoing global pandemic we are now encountering a new kind of patient, patients that have recovered from COVID-19. We hope that this case may contribute to gaining more knowledge about this growing patient population.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

Journal of medical virology - Vol. 94, No. 1 (2021), p. 417-423

Language:

English

Contributors:

Golbets, Evgeny
Kaplan, Alon
Shafat, Tali
Yagel, Yael
Jotkowitz, Alan
Awesat, Jenan
Barski, Leonid

Links:

Volltext

Keywords:

4F4X42SYQ6
Adrenal Cortex Hormones
Adult
Antineoplastic Agents, Immunological
COVID-19
Case Reports
Coronavirus
Cryptogenic Organizing Pneumonia
Humans
Immunocompromised Host
Journal Article
Lymphoma, Large B-Cell, Diffuse
Male
Nasopharynx
Organizing pneumonia
Positron-Emission Tomography
Post COVID-19
Rituximab
SARS coronavirus
SARS-CoV-2

Notes:

Date Completed 23.11.2021

Date Revised 23.11.2021

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1002/jmv.27360

PMID:

34581458

PPN (Catalogue-ID):

NLM332431711