Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver
At least one-third of adults in the United States experience intermittent hypoxia (IH) due to health or living conditions. The majority of these adults suffer with sleep breathing conditions and associated circadian rhythm disorders. The impact of IH on the circadian clock is not well characterized. In the current study, we used an IH mouse model to understand the impact of IH on the circadian gene expression of the canonical clock genes in the central (the brain) and peripheral (the liver) tissues. Gene expression was measured using a Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). CircaCompare was used to evaluate the differential rhythmicity between normoxia and IH. Our observations suggested that the circadian clock in the liver was less sensitive to IH compared to the circadian clock in the brain.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Genes - 12(2021), 10 vom: 16. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Koritala, Bala S C [VerfasserIn] |
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| Links: |
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| Themen: |
CLOCK Proteins |
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| Anmerkungen: |
Date Completed 08.02.2022 Date Revised 08.04.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/genes12101627 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM332211630 |
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| 520 | |a At least one-third of adults in the United States experience intermittent hypoxia (IH) due to health or living conditions. The majority of these adults suffer with sleep breathing conditions and associated circadian rhythm disorders. The impact of IH on the circadian clock is not well characterized. In the current study, we used an IH mouse model to understand the impact of IH on the circadian gene expression of the canonical clock genes in the central (the brain) and peripheral (the liver) tissues. Gene expression was measured using a Quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). CircaCompare was used to evaluate the differential rhythmicity between normoxia and IH. Our observations suggested that the circadian clock in the liver was less sensitive to IH compared to the circadian clock in the brain | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Lee, Yin Yeng |e verfasserin |4 aut | |
| 700 | 1 | |a Bhadri, Shweta S |e verfasserin |4 aut | |
| 700 | 1 | |a Gaspar, Laetitia S |e verfasserin |4 aut | |
| 700 | 1 | |a Stanforth, Corinne |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Gang |e verfasserin |4 aut | |
| 700 | 1 | |a Ruben, Marc D |e verfasserin |4 aut | |
| 700 | 1 | |a Francey, Lauren J |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, David F |e verfasserin |4 aut | |
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