Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy

Copyright © 2020, Spandidos Publications..

Pattern recognition receptors, such as specific nucleotide-binding oligomerization domain protein 2, and their polymorphisms may be involved in the pathogenesis of multiple sclerosis (MS). They may also play a role in the formation of neutralizing antibodies against interferon-β (INF-β), and may exhibit lowered efficacy. Identification of these polymorphisms may be useful for early identification of potential non-responders and to allow for modification of treatment regimens earlier. The differences in genotype distribution and allele frequency of the rs3135499 and rs2066842 NOD2 polymorphisms between patients with MS and healthy controls were analysed in the present study. The group of patients were divided into responders and non-responders to INF-β therapy to evaluate the association of both polymorphisms with response to therapy. No differences in the genotype frequencies between the responder and non-responder groups were observed. However, a statistically significant difference in genotype frequencies of TT homozygotes for rs2066842 between patients with MS and healthy controls was observed (χ2=11.8; P=0.003). A recessive genotype model and allele distribution in rs2066842 suggest that the genotype TT and allele T itself are protective against MS. The odds ratio of 0.12 represents an 8.33x lower risk for MS if an individual has a TT genotype. The significantly lower incidence of the TT genotype of rs2066842 in patients with MS suggests that the TT genotype and T allele may be a protective genetic factor against MS.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:15

Enthalten in:

Biomedical reports - 15(2021), 6 vom: 22. Dez., Seite 100

Sprache:

Englisch

Beteiligte Personen:

Zečkanović, Aida [VerfasserIn]
Maver, Aleš [VerfasserIn]
Ristić, Smiljana [VerfasserIn]
Čizmarević, Nada Starčević [VerfasserIn]
Peterlin, Borut [VerfasserIn]
Lovrečić, Luca [VerfasserIn]

Links:

Volltext

Themen:

INF-β
Journal Article
Multiple sclerosis
NAb
Pattern recognition receptor

Anmerkungen:

Date Revised 22.10.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.3892/br.2021.1476

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM332078396