Characterization of cortical hemodynamic changes following sensory, visual, and speech activation by intraoperative optical imaging utilizing phase-based evaluation methods
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC..
Alterations within cerebral hemodynamics are the intrinsic signal source for a wide variety of neuroimaging techniques. Stimulation of specific functions leads due to neurovascular coupling, to changes in regional cerebral blood flow, oxygenation and volume. In this study, we investigated the temporal characteristics of cortical hemodynamic responses following electrical, tactile, visual, and speech activation for different stimulation paradigms using Intraoperative Optical Imaging (IOI). Image datasets from a total of 22 patients that underwent surgical resection of brain tumors were evaluated. The measured reflectance changes at different light wavelength bands, representing alterations in regional cortical blood volume (CBV), and deoxyhemoglobin (HbR) concentration, were assessed by using Fourier-based evaluation methods. We found a decrease of CBV connected to an increase of HbR within the contralateral primary sensory cortex (SI) in patients that were prolonged (30 s/15 s) electrically stimulated. Additionally, we found differences in amplitude as well as localization of activated areas for different stimulation patterns. Contrary to electrical stimulation, prolonged tactile as well as prolonged visual stimulation are provoking increases in CBV within the corresponding activated areas (SI, visual cortex). The processing of the acquired data from awake patients performing speech tasks reveals areas with increased, as well as areas with decreased CBV. The results lead us to the conclusion, that the CBV decreases in connection with HbR increases in SI are associated to processing of nociceptive stimuli and that stimulation type, as well as paradigm have a nonnegligible impact on the temporal characteristics of the following hemodynamic response.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Human brain mapping - 43(2022), 2 vom: 01. Feb., Seite 598-615 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Oelschlägel, Martin [VerfasserIn] |
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| Links: |
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| Themen: |
Cortical hemodynamics |
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| Anmerkungen: |
Date Completed 28.03.2022 Date Revised 28.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/hbm.25674 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM331318571 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. | ||
| 520 | |a Alterations within cerebral hemodynamics are the intrinsic signal source for a wide variety of neuroimaging techniques. Stimulation of specific functions leads due to neurovascular coupling, to changes in regional cerebral blood flow, oxygenation and volume. In this study, we investigated the temporal characteristics of cortical hemodynamic responses following electrical, tactile, visual, and speech activation for different stimulation paradigms using Intraoperative Optical Imaging (IOI). Image datasets from a total of 22 patients that underwent surgical resection of brain tumors were evaluated. The measured reflectance changes at different light wavelength bands, representing alterations in regional cortical blood volume (CBV), and deoxyhemoglobin (HbR) concentration, were assessed by using Fourier-based evaluation methods. We found a decrease of CBV connected to an increase of HbR within the contralateral primary sensory cortex (SI) in patients that were prolonged (30 s/15 s) electrically stimulated. Additionally, we found differences in amplitude as well as localization of activated areas for different stimulation patterns. Contrary to electrical stimulation, prolonged tactile as well as prolonged visual stimulation are provoking increases in CBV within the corresponding activated areas (SI, visual cortex). The processing of the acquired data from awake patients performing speech tasks reveals areas with increased, as well as areas with decreased CBV. The results lead us to the conclusion, that the CBV decreases in connection with HbR increases in SI are associated to processing of nociceptive stimuli and that stimulation type, as well as paradigm have a nonnegligible impact on the temporal characteristics of the following hemodynamic response | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a cortical hemodynamics | |
| 650 | 4 | |a intraoperative optical imaging | |
| 650 | 4 | |a nociceptive stimuli | |
| 650 | 4 | |a speech activation | |
| 650 | 4 | |a tactile stimulation | |
| 650 | 4 | |a visual | |
| 700 | 1 | |a Polanski, Witold H |e verfasserin |4 aut | |
| 700 | 1 | |a Morgenstern, Ute |e verfasserin |4 aut | |
| 700 | 1 | |a Steiner, Gerald |e verfasserin |4 aut | |
| 700 | 1 | |a Kirsch, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Koch, Edmund |e verfasserin |4 aut | |
| 700 | 1 | |a Schackert, Gabriele |e verfasserin |4 aut | |
| 700 | 1 | |a Sobottka, Stephan B |e verfasserin |4 aut | |
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