Moderate Altitude Residence Reduces Male Colorectal and Female Breast Cancer Mortality More Than Incidence : Therapeutic Implications?

BACKGROUND: Living at moderate altitude may be associated with health benefits, including reduced mortality from male colorectal and female breast cancer. We aimed to determine altitude-dependent incidence and mortality rates of those cancers and put them in the context of altitude-associated lifestyle differences.

METHODS: Incidence cases and deaths of male colorectal cancer (n = 17,712 and 7462) and female breast cancer (n = 33,803 and 9147) from altitude categories between 250 to about 2000 m were extracted from official Austrian registries across 10 years (2008-2017). Altitude-associated differences in health determinants were derived from the Austrian Health Interview Survey (2014).

RESULTS: The age-standardized incidence and mortality rates of male colorectal cancer decreased by 24.0% and 44.2%, and that of female breast cancer by 6.5% and 26.2%, respectively, from the lowest to the highest altitude level. Higher physical activity levels and lower body mass index for both sexes living at higher altitudes were found.

CONCLUSIONS: Living at a moderate altitude was associated with a reduced incidence and (more pronounced) mortality from colorectal and breast cancer. Our results suggest a complex interaction between specific climate conditions and lifestyle behaviours. These observations may, in certain cases, support decision making when changing residence.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:13

Enthalten in:

Cancers - 13(2021), 17 vom: 01. Sept.

Sprache:

Englisch

Beteiligte Personen:

Burtscher, Johannes [VerfasserIn]
Millet, Grégoire P [VerfasserIn]
Renner-Sattler, Kathrin [VerfasserIn]
Klimont, Jeannette [VerfasserIn]
Hackl, Monika [VerfasserIn]
Burtscher, Martin [VerfasserIn]

Links:

Volltext

Themen:

Altitude
Breast
Climate
Colorectal
Disease
Journal Article
Lifestyle

Anmerkungen:

Date Revised 13.09.2021

published: Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.3390/cancers13174420

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM330454846