Simultaneous Follicular Lymphoma and Myelofibrosis : Report of a Case with Review of the Literature

© 2021 Kong et al..

BACKGROUND: Myelofibrosis (MF) is often associated with chronic myeloid leukemia, myelodysplastic syndrome and primary myeloproliferative neoplasms (MPN), but few number cases of malignant lymphoma with myelofibrosis was reported, and a few cases about follicular lymphoma with MF were found. Here we described a case of follicular lymphoma (FL) complicated by myelofibrosis.

CASE PRESENTATION: A 43-year-old man was diagnosed with follicular lymphoma (FL) complicated by MF, besides, the lymphoma staging of this patient was AnnArbor IV B. The cytokines of plated-derived growth factor (PDGF), basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), interleukin-2 (IL-2), and transforming growth factor-β (TGF-β) were positive, while JAK2V617F, MPL, and CALR mutations were negative. After first course of chemotherapy, the peripheral blood and MF improved. The systemic superficial lymph nodes and spleen were significantly narrowed after the third cycle of chemotherapy.

CONCLUSION: The production of various cytokines, such as b-FGF, TNF-α, TGF-β, PDGF, IL-1β, IL-2, IL-6, IL-10, may contribute to the development of MF.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:14

Enthalten in:

OncoTargets and therapy - 14(2021) vom: 01., Seite 4551-4559

Sprache:

Englisch

Beteiligte Personen:

Kong, Ling-Zhijie [VerfasserIn]
Li, Jing [VerfasserIn]
Wang, Rui-Cang [VerfasserIn]
Kang, Lin [VerfasserIn]
Wei, Qiang [VerfasserIn]
Li, Yan [VerfasserIn]

Links:

Volltext

Themen:

Case Reports
Cytokines
Follicular lymphoma
Immunohistochemistry
Myelofibrosis

Anmerkungen:

Date Revised 26.04.2022

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.2147/OTT.S313428

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM330086553