Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients : Extension phase of the GERIA-COVID study

Copyright © 2021 Elsevier Ltd. All rights reserved..

BACKGROUND: The objective of this extension phase of the quasi-experimental GERIA-COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3-month survival in geriatric patients hospitalized for COVID-19.

METHODS: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000 IU per month, or 80,000 IU or 100,000 IU or 200,000 IU every 2-3 months), or daily supplementation with 800 IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration.

RESULTS: 76.1 % (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6 % (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23 [95 %CI: 0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008).

CONCLUSIONS: Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

The Journal of steroid biochemistry and molecular biology - Vol. 213 (2021), p. 105958

Language:

English

Contributors:

Annweiler, Cédric
Beaudenon, Mélinda
Simon, Romain
Guenet, Mialy
Otekpo, Marie
Célarier, Thomas
Gautier, Jennifer
GERIA-COVID study group

Links:

Volltext

Keywords:

*Dietary Supplements
1406-16-2
1C6V77QF41
25-hydroxyvitamin D
A288AR3C9H
Aged, 80 and over
COVID-19
Cardiomyopathies
Case-Control Studies
Cholecalciferol
Clinical Trial
Comorbidity
Drug Administration Schedule
Epidemiology
Female
Health Services for the Aged
Humans
Journal Article
Male
Malnutrition
Neoplasms
Older adults
Proportional Hazards Models
SARS-CoV-2
Treatment
Vitamin D
Vitamin D Deficiency

Notes:

Date Completed 06.10.2021

Date Revised 06.10.2021

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1016/j.jsbmb.2021.105958

PMID:

34332023

PPN (Catalogue-ID):

NLM32993645X