Postvaccinal Encephalitis after ChAdOx1 nCov-19

© 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association..

The global SARS-CoV-2 pandemic has contributed to more than 163 million confirmed infections and 3.3 million deaths worldwide. The severity of the pandemic has led to an unprecedented effort to develop multiple effective vaccines. Due to excellent safety and efficacy data from clinical trials, several vaccines were approved. We report a case series of postvaccinal encephalitis in temporal correlation to vaccination with ChAdOx1 nCov-19. The diagnostic criteria for possible autoimmune encephalitis were fulfilled. Our patients responded well to immunosuppressive therapy with corticosteroids. The incidence has been estimated to be approximately 8 per 10 million vaccine doses. Complication of postvaccinal encephalitis after ChAdOx1 nCoV-19 vaccination still appear to be very rare, but need to be diagnosed and treated adequately. Large pooled data from observational epidemiologic studies are necessary to verify causality. ANN NEUROL 2021;90:506-511.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

Annals of neurology - Vol. 90, No. 3 (2021), p. 506-511

Language:

English

Contributors:

Zuhorn, Frédéric
Graf, Tilmann
Klingebiel, Randolf
Schäbitz, Wolf-Rüdiger
Rogalewski, Andreas

Links:

Volltext

Keywords:

Journal Article
Research Support, Non-U.S. Gov't

Notes:

Date Revised 15.09.2021

published: Print-Electronic

Citation Status In-Process

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1002/ana.26182

PMID:

34324214

PPN (Catalogue-ID):

NLM329858076