Delirium in COVID-19 patients : a multicentric observational study in Italy

© 2021. Fondazione Società Italiana di Neurologia..

INTRODUCTION: Although recent data show that SARS-CoV-2 infection seems to affect the central nervous system (CNS), little is known about the neuropsychiatric effects resulting from this condition. In addition to the well-known neurotrophism of coronaviruses, recent evidence shows also that the "cytokine storm" induced by the infection is at the basis of the neuroinflammation of the CNS. Furthermore, prolonged hospitalization, polypharmacotherapy, and isolation could be at the basis of the onset of delirium in hospitalized COVID patients. This multicentric observational study explores the incidence of the onset of delirium in an Italian cohort of SARS-CoV-2 positive inpatients.

METHODS: Data were collected in the COVIDhospitals of Brescia, Bergamo, Chieti, and Genova. Different socio-demographic, medical, neurological, and pharmacological parameters were collected. As a rapid screening for delirium, the 4AT scale was used. Eighty COVID-19 inpatients (mean age 74.7 ± 14.5 years) met the inclusion criteria (confirmed positivity to the SARS-CoV-2 virus; the presence of delirium and/or psychomotor agitation and/or new onset of other neuropsychiatric symptoms during hospitalization).

RESULTS: The majority of these patients (68.8%) had "hyperactive delirium" subtype. Polypharmacotherapy, current treatment with corticosteroids, and higher age were associated with delirium severity.

CONCLUSION: These data provide an insight into the onset of delirium among COVID-19 patients underlining the need for monitoring, especially in elderly patients, the neuropsychiatric symptoms, and the therapy in order to have shorter hospitalization times and better outcomes.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - Vol. 42, No. 10 (2021), p. 3981-3988

Language:

English

Contributors:

Martinotti, Giovanni
Bonanni, Laura
Barlati, Stefano
Miuli, Andrea
Sepede, Gianna
Prestia, Davide
Trabucco, Alice
Palumbo, Claudia
Massaro, Alessandra
Olcese, Martina
D'Ardes, Damiano
Cipollone, Francesco
Amore, Mario
Bondi, Emi
Russo, Mirella
Carrarini, Claudia
Onofrj, Marco
Sensi, Stefano Luca
Vita, Antonio
di Giannantonio, Massimo

Links:

Volltext

Keywords:

*COVID-19
*Delirium
Aged
Aged, 80 and over
COVID-19
Delirium
Hospitalization
Humans
Italy
Journal Article
Middle Aged
Multicenter Study
Neuroinflammation
Observational Study
SARS-CoV-2
SARS-CoV-2 infection

Notes:

Date Completed 17.09.2021

Date Revised 17.09.2021

published: Print-Electronic

Citation Status MEDLINE

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1007/s10072-021-05461-2

PMID:

34318364

PPN (Catalogue-ID):

NLM329799525