Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions
© 2021. The Author(s)..
Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Nature communications - 12(2021), 1 vom: 25. Aug., Seite 5121 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Smith, Alexander C W [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 24.09.2021 Date Revised 03.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41467-021-25460-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM329769774 |
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| 100 | 1 | |a Smith, Alexander C W |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Opposing roles for striatonigral and striatopallidal neurons in dorsolateral striatum in consolidating new instrumental actions |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 03.04.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a Comparatively little is known about how new instrumental actions are encoded in the brain. Using whole-brain c-Fos mapping, we show that neural activity is increased in the anterior dorsolateral striatum (aDLS) of mice that successfully learn a new lever-press response to earn food rewards. Post-learning chemogenetic inhibition of aDLS disrupts consolidation of the new instrumental response. Similarly, post-learning infusion of the protein synthesis inhibitor anisomycin into the aDLS disrupts consolidation of the new response. Activity of D1 receptor-expressing medium spiny neurons (D1-MSNs) increases and D2-MSNs activity decreases in the aDLS during consolidation. Chemogenetic inhibition of D1-MSNs in aDLS disrupts the consolidation process whereas D2-MSN inhibition strengthens consolidation but blocks the expression of previously learned habit-like responses. These findings suggest that D1-MSNs in the aDLS encode new instrumental actions whereas D2-MSNs oppose this new learning and instead promote expression of habitual actions | ||
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| 700 | 1 | |a Difeliceantonio, Alexandra G |e verfasserin |4 aut | |
| 700 | 1 | |a O'Connor, Richard M |e verfasserin |4 aut | |
| 700 | 1 | |a Ghoshal, Soham |e verfasserin |4 aut | |
| 700 | 1 | |a Romano, Michael F |e verfasserin |4 aut | |
| 700 | 1 | |a Everitt, Barry J |e verfasserin |4 aut | |
| 700 | 1 | |a Kenny, Paul J |e verfasserin |4 aut | |
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