Amphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization
© 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH..
Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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Enthalten in: |
Advanced materials (Deerfield Beach, Fla.) - 33(2021), 42 vom: 01. Okt., Seite e2102489 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ruland, André [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 07.02.2022 Date Revised 07.02.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1002/adma.202102489 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM329747797 |
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520 | |a © 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH. | ||
520 | |a Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces | ||
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700 | 1 | |a Schirmer, Lucas |e verfasserin |4 aut | |
700 | 1 | |a Friedrichs, Jens |e verfasserin |4 aut | |
700 | 1 | |a Meinhardt, Andrea |e verfasserin |4 aut | |
700 | 1 | |a Schwartz, Véronique B |e verfasserin |4 aut | |
700 | 1 | |a Kaiser, Nadine |e verfasserin |4 aut | |
700 | 1 | |a Konradi, Rupert |e verfasserin |4 aut | |
700 | 1 | |a MacDonald, William |e verfasserin |4 aut | |
700 | 1 | |a Helmecke, Tina |e verfasserin |4 aut | |
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700 | 1 | |a Renner, Lars D |e verfasserin |4 aut | |
700 | 1 | |a Werner, Carsten |e verfasserin |4 aut | |
700 | 1 | |a Freudenberg, Uwe |e verfasserin |4 aut | |
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