Amphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization

© 2021 The Authors. Advanced Materials published by Wiley-VCH GmbH..

Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:33

Enthalten in:

Advanced materials (Deerfield Beach, Fla.) - 33(2021), 42 vom: 01. Okt., Seite e2102489

Sprache:

Englisch

Beteiligte Personen:

Ruland, André [VerfasserIn]
Schenker, Saskia [VerfasserIn]
Schirmer, Lucas [VerfasserIn]
Friedrichs, Jens [VerfasserIn]
Meinhardt, Andrea [VerfasserIn]
Schwartz, Véronique B [VerfasserIn]
Kaiser, Nadine [VerfasserIn]
Konradi, Rupert [VerfasserIn]
MacDonald, William [VerfasserIn]
Helmecke, Tina [VerfasserIn]
Sikosana, Melissa K L N [VerfasserIn]
Valtin, Juliane [VerfasserIn]
Hahn, Dominik [VerfasserIn]
Renner, Lars D [VerfasserIn]
Werner, Carsten [VerfasserIn]
Freudenberg, Uwe [VerfasserIn]

Links:

Volltext

Themen:

3WJQ0SDW1A
44LJ2U959V
78VO7F77PN
91XW058U2C
Adsorptive surface functionalization
Anti-Infective Agents
Antimicrobial surface properties
Arginyl-glycyl-aspartic acid
Biocompatible Materials
Cell-instructive properties
Cytokines
Glycosaminoglycans
Journal Article
Maleates
Maleic acid
Oligopeptides
Polyethylene Glycols
Polymers
Styrene
Styrene-maleic anhydride copolymers

Anmerkungen:

Date Completed 07.02.2022

Date Revised 07.02.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/adma.202102489

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM329747797