Cytotoxicity of Amino-BODIPY Modulated via Conjugation with 2-Phenyl-3-Hydroxy-4(1H)-Quinolinones
© 2021 The Authors. Published by Wiley-VCH GmbH..
The combination of cytotoxic amino-BODIPY dye and 2-phenyl-3-hydroxy-4(1H)-quinolinone (3-HQ) derivatives into one molecule gave rise to selective activity against lymphoblastic or myeloid leukemia and the simultaneous disappearance of the cytotoxicity against normal cells. Both species' conjugation can be realized via a disulfide linker cleavable in the presence of glutathione characteristic for cancer cells. The cleavage liberating the free amino-BODIPY dye and 3-HQ derivative can be monitored by ratiometric fluorescence or by the OFF-ON effect of the amino-BODIPY dye. A similar cytotoxic activity is observed when the amino-BODIPY dye and 3-HQ derivative are connected through a non-cleavable maleimide linker. The work reports the synthesis of several conjugates, the study of their cleavage inside cells, and cytotoxic screening.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
ChemistryOpen - 10(2021), 11 vom: 11. Nov., Seite 1104-1110 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Porubský, Martin [VerfasserIn] |
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| Links: |
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| Themen: |
Amino-BODIPY dyes |
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| Anmerkungen: |
Date Completed 13.01.2022 Date Revised 08.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/open.202100025 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329703137 |
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| 520 | |a © 2021 The Authors. Published by Wiley-VCH GmbH. | ||
| 520 | |a The combination of cytotoxic amino-BODIPY dye and 2-phenyl-3-hydroxy-4(1H)-quinolinone (3-HQ) derivatives into one molecule gave rise to selective activity against lymphoblastic or myeloid leukemia and the simultaneous disappearance of the cytotoxicity against normal cells. Both species' conjugation can be realized via a disulfide linker cleavable in the presence of glutathione characteristic for cancer cells. The cleavage liberating the free amino-BODIPY dye and 3-HQ derivative can be monitored by ratiometric fluorescence or by the OFF-ON effect of the amino-BODIPY dye. A similar cytotoxic activity is observed when the amino-BODIPY dye and 3-HQ derivative are connected through a non-cleavable maleimide linker. The work reports the synthesis of several conjugates, the study of their cleavage inside cells, and cytotoxic screening | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a amino-BODIPY dyes | |
| 650 | 4 | |a cytotoxic activity | |
| 650 | 4 | |a disulfide linkers | |
| 650 | 4 | |a glutathione | |
| 650 | 4 | |a hydroxyquinolinones | |
| 650 | 7 | |a Disulfides |2 NLM | |
| 650 | 7 | |a Fluorescent Dyes |2 NLM | |
| 650 | 7 | |a Quinolones |2 NLM | |
| 650 | 7 | |a Glutathione |2 NLM | |
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| 700 | 1 | |a Vychodilová, Kristýna |e verfasserin |4 aut | |
| 700 | 1 | |a Milićević, David |e verfasserin |4 aut | |
| 700 | 1 | |a Buděšinský, Miloš |e verfasserin |4 aut | |
| 700 | 1 | |a Stanková, Jarmila |e verfasserin |4 aut | |
| 700 | 1 | |a Džubák, Petr |e verfasserin |4 aut | |
| 700 | 1 | |a Hajdúch, Marián |e verfasserin |4 aut | |
| 700 | 1 | |a Hlaváč, Jan |e verfasserin |4 aut | |
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