Construction of Bulky Ligand Libraries by Ru(II)-Catalyzed P(III)-Assisted ortho-C-H Secondary Alkylation
Modification of commercially available biaryl monophosphine ligands via ruthenium(II)-catalyzed P(III)-directed-catalyzed ortho C-H secondary alkylation is described. The use of highly ring-strained norbornene as a secondary alkylating reagent is the key to this transformation. A series of highly bulky ligands with a norbornyl group were obtained in excellent yields. The modified ligands with secondary alkyl group outperformed common substituted phosphines in the Suzuki-Miyaura cross-coupling reaction at a ppm mole level of Pd catalyst.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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Enthalten in: |
The Journal of organic chemistry - 86(2021), 17 vom: 03. Sept., Seite 11915-11925 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Li, Ming [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Revised 07.09.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.1021/acs.joc.1c01329 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM329673424 |
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650 | 4 | |a Journal Article | |
700 | 1 | |a Tao, Jun-Yang |e verfasserin |4 aut | |
700 | 1 | |a Wang, Liang-Neng |e verfasserin |4 aut | |
700 | 1 | |a Li, Jia-Wei |e verfasserin |4 aut | |
700 | 1 | |a Liu, Yue-Jin |e verfasserin |4 aut | |
700 | 1 | |a Zeng, Ming-Hua |e verfasserin |4 aut | |
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