Construction of Bulky Ligand Libraries by Ru(II)-Catalyzed P(III)-Assisted ortho-C-H Secondary Alkylation

Modification of commercially available biaryl monophosphine ligands via ruthenium(II)-catalyzed P(III)-directed-catalyzed ortho C-H secondary alkylation is described. The use of highly ring-strained norbornene as a secondary alkylating reagent is the key to this transformation. A series of highly bulky ligands with a norbornyl group were obtained in excellent yields. The modified ligands with secondary alkyl group outperformed common substituted phosphines in the Suzuki-Miyaura cross-coupling reaction at a ppm mole level of Pd catalyst.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:86

Enthalten in:

The Journal of organic chemistry - 86(2021), 17 vom: 03. Sept., Seite 11915-11925

Sprache:

Englisch

Beteiligte Personen:

Li, Ming [VerfasserIn]
Tao, Jun-Yang [VerfasserIn]
Wang, Liang-Neng [VerfasserIn]
Li, Jia-Wei [VerfasserIn]
Liu, Yue-Jin [VerfasserIn]
Zeng, Ming-Hua [VerfasserIn]

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Themen:

Journal Article

Anmerkungen:

Date Revised 07.09.2021

published: Print-Electronic

Citation Status PubMed-not-MEDLINE

doi:

10.1021/acs.joc.1c01329

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM329673424