α and θ oscillations in the subthalamic nucleus are potential biomarkers for Parkinson's disease with depressive symptoms

Copyright © 2021 Elsevier Ltd. All rights reserved..

INTRODUCTION: Abnormal α oscillations in the bed nucleus of stria terminalis and subgenual cingulate of patients with depression correlate with symptom severity. Some Parkinson's disease (PD) patients also have abnormal θ-α oscillations in the subthalamic nucleus (STN). However, the relationship between abnormal θ-α oscillations and depressive symptoms in PD patients has not been determined. This study explored the correlation between α and θ oscillations of the STN and depressive symptoms in PD patients.

METHODS: We conducted a retrospective case-control study on 36 PD patients with (dPD group) or without depressive symptoms (nPD group), analyzing the difference in the average power spectral density (PSD) of α and θ oscillations of the local field potential (LFP) recorded in the STN during deep brain stimulation (DBS), and their correlation with the Hamilton depression rating scale (HAMD) of PD patients during the same period.

RESULTS: The dPD group had a higher PSD of α oscillations and a lower PSD of θ oscillations in the left ventral STN. The PSD of α oscillations of the left ventral STN were positively correlated with the severity of depressive symptoms, whereas the PSD of θ oscillations of this location was negatively correlated with severity of depressive symptoms. The PSD of α and θ oscillations did not correlate with motor symptoms, sleep quality, or quality of life score.

CONCLUSION: Abnormal α and θ oscillations of the left ventral STN could be used as biomarkers of PD with depressive symptoms, which might guide STN-DBS treatment.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:90

Enthalten in:

Parkinsonism & related disorders - 90(2021) vom: 30. Sept., Seite 98-104

Sprache:

Englisch

Beteiligte Personen:

Sun, Yujia [VerfasserIn]
Wang, Zhuyong [VerfasserIn]
Hu, Kai [VerfasserIn]
Mo, Yixiang [VerfasserIn]
Cao, Peihua [VerfasserIn]
Hou, Xusheng [VerfasserIn]
He, Xiaozheng [VerfasserIn]
Zhang, Shizhong [VerfasserIn]
Xue, Sha [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers
Deep brain stimulation
Depressive symptoms
Journal Article
Oscillation
Parkinson's disease
Subthalamic nucleus

Anmerkungen:

Date Completed 11.02.2022

Date Revised 11.02.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.parkreldis.2021.07.023

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM329631799