Melanocytic marker Melan-A detects molluscum contagiosum bodies

Melan-A is one of the most commonly used immunohistochemical assays (IHC) in dermatopathology laboratories to detect the presence and outline the distribution of melanocytes. It is a cytoplasmic stain that detects a melanocyte-specific cytoplasmic protein involved in the formation of stage II melanosomes. Clinically, Melan-A is primarily used to detect and confirm melanocytic tumors although it is also positively expressed in adrenal cortical tumors and sex cord stromal tumors. We found that Melan-A also detected and highlighted Henderson-Patterson bodies of molluscum poxvirus. To determine if other melanocytic markers detect molluscum contagiosum bodies, S-100, HMB-45, MITF, and SOX-10 were also tested. In 15 tested molluscum cases, Melan-A stains were positive in all cases, whereas the other tested melanocytic markers were negative. Our results confirm that Melan-A is very sensitive in detecting molluscum contagiosum bodies and could be clinically useful to supplement the hematoxylin and eosin (H&E) in cases that are very inflamed or only have limited biopsy material.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:45

Enthalten in:

Journal of histotechnology - 45(2022), 1 vom: 02. März, Seite 36-38

Sprache:

Englisch

Beteiligte Personen:

Vincek, Erik [VerfasserIn]
Rudnick, Eric [VerfasserIn]

Links:

Volltext

Themen:

Biomarkers, Tumor
HMB-45
Henderson–Patterson bodies
Journal Article
MART-1
MART-1 Antigen
MITF
Melan-A
Melanoma-Specific Antigens
Molluscum contagiosum
S-100
SOX-10

Anmerkungen:

Date Completed 04.05.2022

Date Revised 04.05.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1080/01478885.2021.1964872

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM329512579