Irreversible post-translational modifications - Emerging cardiovascular risk factors

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved..

Despite the introduction of lipid-lowering drugs, antihypertensives, antiplatelet and anticoagulation therapies for primary prevention of cardiovascular and heart diseases (CVD), it remains the number one cause of death globally, raising the question for novel/further essential factors besides traditional risk factors such as cholesterol, blood pressure and coagulation. With continuous identification and characterization of non-enzymatic post-translationally modified isoforms of proteins and lipoproteins, it is becoming increasingly clear that irreversible non-enzymatic post-translational modifications (nPTMs) alter the biological functions of native proteins and lipoproteins thereby transforming innate serum components into CVD mediators. In particular renal insufficiency and metabolic imbalance are major contributors to the systemically increased concentration of reactive metabolites and thus increased frequency of nPTMs, promoting multi-morbid disease development centering around cardiovascular disease. nPTMs are significantly involved in the onset and progression of cardiovascular disease and represent a significant and novel risk factor. These insights represent potentially new avenues for risk assessment, prevention and therapy. This review chapter summarizes all forms of nPTMs found in CKD and under metabolic imbalance and discusses the biochemical connections between molecular alterations and the pathological impact on increased cardiovascular risk, novel nPTM-associated non-traditional cardiovascular risk factors, and clinical implication of nPTM in cardiovascular disease.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:86

Enthalten in:

Molecular aspects of medicine - 86(2022) vom: 26. Aug., Seite 101010

Sprache:

Englisch

Beteiligte Personen:

Wu, Zhuojun [VerfasserIn]
Jankowski, Vera [VerfasserIn]
Jankowski, Joachim [VerfasserIn]

Links:

Volltext

Themen:

Cardiovascular diseases
Journal Article
Lipoproteins
Metabolic disorder
Modification
Post-translational
Renal diseases
Research Support, Non-U.S. Gov't
Review

Anmerkungen:

Date Completed 16.08.2022

Date Revised 23.08.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.mam.2021.101010

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM329481274