Aberrant somatosensory phase synchronization in children with hemiplegic cerebral palsy
Copyright © 2021 Elsevier B.V. All rights reserved..
Children with hemiplegic cerebral palsy (HCP) often show disturbances of somatosensation. Despite extensive evidence of somatosensory deficits, neurophysiological alterations associated with somatosensory deficits in children with HCP have not been elucidated. Here, we aim to assess phase synchrony within and between contralateral primary (S1) and secondary (S2) somatosensory areas in children with HCP. Intra-regional and inter-regional phase synchronizations within and between S1 and S2 were estimated from somatosensory evoked fields (SEFs) in response to passive pneumatic stimulation of contralateral upper extremities and recorded with pediatric magnetoencephalography (MEG) in children with HCP and typically developing (TD) children. We found aberrant phase synchronizations within S1 and between S1 and S2 in both hemispheres in children with HCP. Specifically, the less-affected (LA) hemisphere demonstrated diminished phase synchronizations after the stimulus onset up to ~120 ms compared to the more-affected (MA) hemisphere and the dominant hemisphere of TD children, while the MA hemisphere showed enhanced phase synchronizations after ~100 ms compared to the LA hemisphere and the TD dominant hemisphere. Our findings indicate abnormal somatosensory functional connectivity in both hemispheres of children with HCP.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:762 |
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| Enthalten in: |
Neuroscience letters - 762(2021) vom: 25. Sept., Seite 136169 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Yanlong [VerfasserIn] |
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| Links: |
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| Themen: |
Cerebral palsy |
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| Anmerkungen: |
Date Completed 20.01.2022 Date Revised 28.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2021.136169 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329345249 |
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| 245 | 1 | 0 | |a Aberrant somatosensory phase synchronization in children with hemiplegic cerebral palsy |
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| 500 | |a Date Revised 28.09.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier B.V. All rights reserved. | ||
| 520 | |a Children with hemiplegic cerebral palsy (HCP) often show disturbances of somatosensation. Despite extensive evidence of somatosensory deficits, neurophysiological alterations associated with somatosensory deficits in children with HCP have not been elucidated. Here, we aim to assess phase synchrony within and between contralateral primary (S1) and secondary (S2) somatosensory areas in children with HCP. Intra-regional and inter-regional phase synchronizations within and between S1 and S2 were estimated from somatosensory evoked fields (SEFs) in response to passive pneumatic stimulation of contralateral upper extremities and recorded with pediatric magnetoencephalography (MEG) in children with HCP and typically developing (TD) children. We found aberrant phase synchronizations within S1 and between S1 and S2 in both hemispheres in children with HCP. Specifically, the less-affected (LA) hemisphere demonstrated diminished phase synchronizations after the stimulus onset up to ~120 ms compared to the more-affected (MA) hemisphere and the dominant hemisphere of TD children, while the MA hemisphere showed enhanced phase synchronizations after ~100 ms compared to the LA hemisphere and the TD dominant hemisphere. Our findings indicate abnormal somatosensory functional connectivity in both hemispheres of children with HCP | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Cerebral palsy | |
| 650 | 4 | |a Functional connectivity | |
| 650 | 4 | |a Magnetoencephalography | |
| 650 | 4 | |a Phase synchronization | |
| 650 | 4 | |a Primary somatosensory cortex | |
| 650 | 4 | |a Secondary somatosensory cortex | |
| 700 | 1 | |a Renoul, Emmanuelle |e verfasserin |4 aut | |
| 700 | 1 | |a Acord, Stephanie |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Yvette R |e verfasserin |4 aut | |
| 700 | 1 | |a Marks, Warren |e verfasserin |4 aut | |
| 700 | 1 | |a Alexandrakis, George |e verfasserin |4 aut | |
| 700 | 1 | |a Papadelis, Christos |e verfasserin |4 aut | |
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