PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis
© 2021. The Author(s)..
The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic cells (DC) interact with the gut microbiome and antigens and are important in maintaining gut homeostasis. Here, we investigate DC transcriptome, phenotype and function in five anatomical locations of the gut lamina propria (LP) which constitute different antigenic environments. We show that DC from distinct gut LP compartments induce distinct T cell differentiation and cytokine secretion. We also find that PD-L1+ DC in the duodenal LP and XCR1+ DC in the colonic LP comprise distinct tolerogenic DC subsets that are crucial for gut homeostasis. Mice lacking PD-L1+ and XCR1+ DC have a proinflammatory gut milieu associated with an increase in Th1/Th17 cells and a decrease in Treg cells and have exacerbated disease in the models of 5-FU-induced mucositis and DSS-induced colitis. Our findings identify PD-L1+ and XCR1+ DC as region-specific physiologic regulators of intestinal homeostasis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Nature communications - 12(2021), 1 vom: 13. Aug., Seite 4907 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Moreira, Thais G [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
B7-H1 Antigen |
|---|
| Anmerkungen: |
Date Completed 30.08.2021 Date Revised 26.02.2024 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41467-021-25115-3 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM329334905 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM329334905 | ||
| 003 | DE-627 | ||
| 005 | 20240229153612.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-021-25115-3 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1306.xml |
| 035 | |a (DE-627)NLM329334905 | ||
| 035 | |a (NLM)34389726 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Moreira, Thais G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.08.2021 | ||
| 500 | |a Date Revised 26.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a The intestinal mucosa constitutes an environment of closely regulated immune cells. Dendritic cells (DC) interact with the gut microbiome and antigens and are important in maintaining gut homeostasis. Here, we investigate DC transcriptome, phenotype and function in five anatomical locations of the gut lamina propria (LP) which constitute different antigenic environments. We show that DC from distinct gut LP compartments induce distinct T cell differentiation and cytokine secretion. We also find that PD-L1+ DC in the duodenal LP and XCR1+ DC in the colonic LP comprise distinct tolerogenic DC subsets that are crucial for gut homeostasis. Mice lacking PD-L1+ and XCR1+ DC have a proinflammatory gut milieu associated with an increase in Th1/Th17 cells and a decrease in Treg cells and have exacerbated disease in the models of 5-FU-induced mucositis and DSS-induced colitis. Our findings identify PD-L1+ and XCR1+ DC as region-specific physiologic regulators of intestinal homeostasis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a B7-H1 Antigen |2 NLM | |
| 650 | 7 | |a Cytokines |2 NLM | |
| 650 | 7 | |a Receptors, Chemokine |2 NLM | |
| 650 | 7 | |a XC chemokine receptor 1, mouse |2 NLM | |
| 700 | 1 | |a Mangani, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Cox, Laura M |e verfasserin |4 aut | |
| 700 | 1 | |a Leibowitz, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Lobo, Eduardo L C |e verfasserin |4 aut | |
| 700 | 1 | |a Oliveira, Mariana A |e verfasserin |4 aut | |
| 700 | 1 | |a Gauthier, Christian D |e verfasserin |4 aut | |
| 700 | 1 | |a Nakagaki, Brenda N |e verfasserin |4 aut | |
| 700 | 1 | |a Willocq, Valerie |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Anya |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Lydia |e verfasserin |4 aut | |
| 700 | 1 | |a Lima, David C A |e verfasserin |4 aut | |
| 700 | 1 | |a Murugaiyan, Gopal |e verfasserin |4 aut | |
| 700 | 1 | |a Butovsky, Oleg |e verfasserin |4 aut | |
| 700 | 1 | |a Gabriely, Galina |e verfasserin |4 aut | |
| 700 | 1 | |a Anderson, Ana C |e verfasserin |4 aut | |
| 700 | 1 | |a Rezende, Rafael M |e verfasserin |4 aut | |
| 700 | 1 | |a Faria, Ana Maria C |e verfasserin |4 aut | |
| 700 | 1 | |a Weiner, Howard L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature communications |d 2010 |g 12(2021), 1 vom: 13. Aug., Seite 4907 |w (DE-627)NLM199274525 |x 2041-1723 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2021 |g number:1 |g day:13 |g month:08 |g pages:4907 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41467-021-25115-3 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2021 |e 1 |b 13 |c 08 |h 4907 | ||