Regulatory role of long non-coding RNA in peripheral nerve injury and neural regeneration

OBJECTIVE: To summarize the regulatory role of long non-coding RNA (lncRNA) in peripheral nerve injury (PNI) and neural regeneration.

METHODS: The characteristics and mechanisms of lncRNA were summarized and its regulatory role in PNI and neural regeneration were elaborated by referring to relevant domestic and foreign literature in recent years.

RESULTS: Neuropathic pain and denervated muscle atrophy are common complications of PNI, affecting patients' quality of life. Numerous lncRNAs are upregulated after PNI, which promote the progress of neuropathic pain by regulating nerve excitability and neuroinflammation. Several lncRNAs are found to promote the progress of denervated muscle atrophy. Importantly, peripheral nerve regeneration occurs after PNI. LncRNAs promote peripheral nerve regeneration through promoting neuronal axonal outgrowth and the proliferation and migration of Schwann cells.

CONCLUSION: At present, the research on lncRNA regulating PNI and neural regeneration is still in its infancy. The specific mechanism remains to be further explored. How to achieve clinical translation of experimental results is also a major challenge for future research.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:35

Enthalten in:

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery - 35(2021), 8 vom: 15. Aug., Seite 1051-1056

Sprache:

Chinesisch

Beteiligte Personen:

Peng, Ying [VerfasserIn]
Lin, Haodong [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Long non-coding RNA
Neural regeneration
Peripheral nerve injury
RNA, Long Noncoding
Regulation

Anmerkungen:

Date Completed 16.08.2021

Date Revised 25.04.2022

published: Print

Citation Status MEDLINE

doi:

10.7507/1002-1892.202103107

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM329312170