Synthesis of Lipopeptides by CLipPA Chemistry
© 2021. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature..
Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol group to afford S-lipidated lipopeptides. A generalized procedure for the synthesis of S-lipopeptides is described which facilities rapid preparation of tens of analogs of lipopeptides from a single thiolated polypeptide precursor.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2355 |
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| Enthalten in: |
Methods in molecular biology (Clifton, N.J.) - 2355(2021) vom: 12., Seite 253-263 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yim, Victor [VerfasserIn] |
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| Links: |
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| Themen: |
Amino Acids |
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| Anmerkungen: |
Date Completed 11.01.2022 Date Revised 11.01.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/978-1-0716-1617-8_19 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM329307460 |
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| 520 | |a Lipidation of polypeptides with a fatty acid to form N-linked lipopeptides can be a time consuming process due to the need to mask other reactive function groups present on the side chains of amino acids. Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technology enables the direct lipidation of unprotected peptides containing a free thiol group to afford S-lipidated lipopeptides. A generalized procedure for the synthesis of S-lipopeptides is described which facilities rapid preparation of tens of analogs of lipopeptides from a single thiolated polypeptide precursor | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a CLipPA | |
| 650 | 4 | |a Lipopeptides | |
| 650 | 4 | |a S-lipidation | |
| 650 | 4 | |a Thiol-ene | |
| 650 | 7 | |a Amino Acids |2 NLM | |
| 650 | 7 | |a Fatty Acids |2 NLM | |
| 650 | 7 | |a Lipopeptides |2 NLM | |
| 650 | 7 | |a Sulfhydryl Compounds |2 NLM | |
| 650 | 7 | |a Cysteine |2 NLM | |
| 650 | 7 | |a K848JZ4886 |2 NLM | |
| 700 | 1 | |a Hermant, Yann O |e verfasserin |4 aut | |
| 700 | 1 | |a Harris, Paul W R |e verfasserin |4 aut | |
| 700 | 1 | |a Brimble, Margaret A |e verfasserin |4 aut | |
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