Comprehensive Laboratory Data Analysis to Predict the Clinical Severity of Coronavirus Disease 2019 in 1,952 Patients in Daegu, Korea

BACKGROUND: Laboratory parameter abnormalities are commonly observed in COVID-19 patients; however, their clinical significance remains controversial. We assessed the prevalence, characteristics, and clinical impact of laboratory parameters in COVID-19 patients hospitalized in Daegu, Korea.

METHODS: We investigated the clinical and laboratory parameters of 1,952 COVID-19 patients on admission in nine hospitals in Daegu, Korea. The average patient age was 58.1 years, and 700 (35.9%) patients were men. The patients were classified into mild (N=1,612), moderate (N=294), and severe (N=46) disease groups based on clinical severity scores. We used chi-square test, multiple comparison analysis, and multinomial logistic regression to evaluate the correlation between laboratory parameters and disease severity.

RESULTS: Laboratory parameters on admission in the three disease groups were significantly different in terms of hematologic (Hb, Hct, white blood cell count, lymphocyte%, and platelet count), coagulation (prothrombin time and activated partial thromboplastin time), biochemical (albumin, aspartate aminotransferase, alanine aminotransferase, lactate, blood urea nitrogen, creatinine, and electrolytes), inflammatory (C-reactive protein and procalcitonin), cardiac (creatinine kinase MB isoenzyme and troponin I), and molecular virologic (Ct value of SARS-CoV-2 RdRP gene) parameters. Relative lymphopenia, prothrombin time prolongation, and hypoalbuminemia were significant indicators of COVID-19 severity. Patients with both hypoalbuminemia and lymphopenia had a higher risk of severe COVID-19.

CONCLUSIONS: Laboratory parameter abnormalities on admission are common, are significantly associated with clinical severity, and can serve as independent predictors of COVID-19 severity. Monitoring the laboratory parameters, including albumin and lymphocyte count, is crucial for timely treatment of COVID-19.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:42

Enthalten in:

Annals of laboratory medicine - 42(2022), 1 vom: 01. Jan., Seite 24-35

Sprache:

Englisch

Beteiligte Personen:

Yoo, Eun-Hyung [VerfasserIn]
Chang, Soon Hee [VerfasserIn]
Song, Do-Young [VerfasserIn]
Lee, Chae Hoon [VerfasserIn]
Cheong, Gyu Young [VerfasserIn]
Park, Sunggyun [VerfasserIn]
Lee, Jae Hee [VerfasserIn]
Lee, Sooin [VerfasserIn]
Kwak, Sang-Gyu [VerfasserIn]
Jeon, Chang-Ho [VerfasserIn]
Song, Kyung Eun [VerfasserIn]

Links:

Volltext

Themen:

Coronavirus disease 2019
Hypoalbuminemia
Journal Article
Laboratory parameters
Lymphopenia
Prothrombin time
Severity

Anmerkungen:

Date Completed 17.09.2021

Date Revised 25.04.2022

published: Print

Citation Status MEDLINE

doi:

10.3343/alm.2022.42.1.24

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM329184237