Beryllium in contaminated soils : Implication of beryllium bioaccessibility by different exposure pathways
Copyright © 2021 Elsevier B.V. All rights reserved..
Inhalation exposure and beryllium (Be) toxicity are well-known, but research on bioaccessibility from soils via different exposure pathways is limited. This study examined soils from a legacy radioactive waste disposal site using in vitro ingestion (Solubility Bioaccessibility Research Consortium [SBRC], physiologically based extraction test [PBET], in vitro gastrointestinal [IVG]), inhalation (simulated epithelial lung fluid [SELF]) and dynamic two-stage bioaccessibility (TBAc) methods, as well as 0.43 M HNO3 extraction. The results showed, 70 ± 4.8%, 56 ± 16.8% and 58 ± 5.7% of total Be were extracted (gastric phase [GP] + intestinal phase [IP]) in the SBRC, PBET, and IVG methods, respectively. Similar bioaccessibility of Be (~18%) in PBET-IP and SELF was due to chelating agents in the extractant. Moreover, TBAc-IP showed higher extraction (20.8 ± 2.0%) in comparison with the single-phase (SBRC-IP) result (4.8 ± 0.23%), suggesting increased Be bioaccessibility and toxicity in the gastrointestinal tract when the contamination derives from the inhalation route. The results suggested Be bioaccessibility depends on solution pH; time of extraction; soil reactive fractions (organic-inorganic); particle size, and the presence of chelating agents in the fluid. This study has significance for understanding Be bioaccessibility via different exposure routes and the application of risk-based management of Be-contaminated sites.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:421 |
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Enthalten in: |
Journal of hazardous materials - 421(2022) vom: 05. Jan., Seite 126757 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Islam, Md Rashidul [VerfasserIn] |
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Links: |
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Themen: |
Arsenic |
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Anmerkungen: |
Date Completed 26.10.2021 Date Revised 26.10.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.jhazmat.2021.126757 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM328968323 |
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520 | |a Copyright © 2021 Elsevier B.V. All rights reserved. | ||
520 | |a Inhalation exposure and beryllium (Be) toxicity are well-known, but research on bioaccessibility from soils via different exposure pathways is limited. This study examined soils from a legacy radioactive waste disposal site using in vitro ingestion (Solubility Bioaccessibility Research Consortium [SBRC], physiologically based extraction test [PBET], in vitro gastrointestinal [IVG]), inhalation (simulated epithelial lung fluid [SELF]) and dynamic two-stage bioaccessibility (TBAc) methods, as well as 0.43 M HNO3 extraction. The results showed, 70 ± 4.8%, 56 ± 16.8% and 58 ± 5.7% of total Be were extracted (gastric phase [GP] + intestinal phase [IP]) in the SBRC, PBET, and IVG methods, respectively. Similar bioaccessibility of Be (~18%) in PBET-IP and SELF was due to chelating agents in the extractant. Moreover, TBAc-IP showed higher extraction (20.8 ± 2.0%) in comparison with the single-phase (SBRC-IP) result (4.8 ± 0.23%), suggesting increased Be bioaccessibility and toxicity in the gastrointestinal tract when the contamination derives from the inhalation route. The results suggested Be bioaccessibility depends on solution pH; time of extraction; soil reactive fractions (organic-inorganic); particle size, and the presence of chelating agents in the fluid. This study has significance for understanding Be bioaccessibility via different exposure routes and the application of risk-based management of Be-contaminated sites | ||
650 | 4 | |a Journal Article | |
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650 | 4 | |a Beryllium | |
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700 | 1 | |a Naidu, Ravi |e verfasserin |4 aut | |
700 | 1 | |a Payne, Timothy E |e verfasserin |4 aut | |
700 | 1 | |a Johansen, Mathew P |e verfasserin |4 aut | |
700 | 1 | |a Bari, A S M Fazle |e verfasserin |4 aut | |
700 | 1 | |a Rahman, Mohammad Mahmudur |e verfasserin |4 aut | |
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