The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009-2018

© 2021. The Author(s)..

BACKGROUND: Identifying ineffective practices that have been used in oncology is important in reducing wasted resources and harm. We sought to examine the prevalence of practices that are being used but have been shown in RCTs to be ineffective (medical reversals) in published oncology studies.

METHODS: We cross-sectionally analyzed studies published in three high-impact oncology medical journals (2009-2018). We abstracted data relating to the frequency and characterization of medical reversals.

RESULTS: Of the 64 oncology reversals, medications (44%) represented the most common intervention type (39% were targeted). Fourteen (22%) were funded by pharmaceutical/industry only and 56% were funded by an organization other than pharmaceutical/industry. The median number of years that the practice had been in use prior to the reversal study was 9 years (range 1-50 years).

CONCLUSION: Here we show that oncology reversals most often involve the administration of medications, have been practiced for years, and are often identified through studies funded by non-industry organizations.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:21

Enthalten in:

BMC cancer - 21(2021), 1 vom: 03. Aug., Seite 889

Sprache:

Englisch

Beteiligte Personen:

Haslam, Alyson [VerfasserIn]
Gill, Jennifer [VerfasserIn]
Crain, Tyler [VerfasserIn]
Herrera-Perez, Diana [VerfasserIn]
Chen, Emerson Y [VerfasserIn]
Hilal, Talal [VerfasserIn]
Kim, Myung S [VerfasserIn]
Prasad, Vinay [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Low-value care
Medical reversal
Oncology

Anmerkungen:

Date Completed 18.10.2021

Date Revised 18.10.2021

published: Electronic

Citation Status MEDLINE

doi:

10.1186/s12885-021-08632-8

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM328887900