Structurally Diverse Synthesis of Five-, Six-, and Seven-Membered Benzosultams through Electrochemical Cyclization
We have developed a metal- and oxidant-free approach to structurally diverse synthesis of benzosultams from aryl sulfonamides through an electrochemical cyclization. Upon variation of the ortho substituent on aryl sulfonamides, five-, six-, and seven-membered benzosultams were efficiently assembled in an atom- and resource-economic manner. The generality of the process is demonstrated by the formation of five- to seven-membered cyclic products from 42 substrates bearing substituents with different electronic effects and steric hindrance.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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Enthalten in: |
Organic letters - 23(2021), 16 vom: 20. Aug., Seite 6326-6331 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Liu, Aiyun [VerfasserIn] |
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Anmerkungen: |
Date Revised 20.08.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.1021/acs.orglett.1c02128 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM328869481 |
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520 | |a We have developed a metal- and oxidant-free approach to structurally diverse synthesis of benzosultams from aryl sulfonamides through an electrochemical cyclization. Upon variation of the ortho substituent on aryl sulfonamides, five-, six-, and seven-membered benzosultams were efficiently assembled in an atom- and resource-economic manner. The generality of the process is demonstrated by the formation of five- to seven-membered cyclic products from 42 substrates bearing substituents with different electronic effects and steric hindrance | ||
650 | 4 | |a Journal Article | |
700 | 1 | |a Guo, Tiantian |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Shuangshuang |e verfasserin |4 aut | |
700 | 1 | |a Yang, Han |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Qi |e verfasserin |4 aut | |
700 | 1 | |a Chai, Yonghai |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Shengyong |e verfasserin |4 aut | |
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