Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants

© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association..

INTRODUCTION: Little is known about the association between speech-in-noise (SiN) hearing impairment and dementia.

METHODS: In 82,039 dementia-free participants aged ≥60 years were selected from the UK Biobank. Cox proportional-hazards models were used to investigate whether SiN hearing impairment is associated with an increased risk of incident dementia.

RESULTS: Over 11 years of follow-up (median = 10.1), 1285 participants developed dementia. Insufficient and poor SiN hearing were associated with a 61% (hazard ratio [HR] = 1.61, 95% confidence [CI] 1.41-1.84) and 91% (HR = 1.91, 95% CI 1.55-2.36) increased risk of developing dementia, respectively, compared to normal SiN hearing. The association remained similar when restricting to follow-up intervals of ≤3, >3 to  <6, >6 to <9, and >9 years. There was limited evidence for mediation through depressive symptoms and social isolation.

DISCUSSION: SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor.

Medienart:

E-Artikel

Erscheinungsjahr:

2022

Erschienen:

2022

Enthalten in:

Zur Gesamtaufnahme - volume:18

Enthalten in:

Alzheimer's & dementia : the journal of the Alzheimer's Association - 18(2022), 3 vom: 18. März, Seite 445-456

Sprache:

Englisch

Beteiligte Personen:

Stevenson, Jonathan S [VerfasserIn]
Clifton, Lei [VerfasserIn]
Kuźma, Elżbieta [VerfasserIn]
Littlejohns, Thomas J [VerfasserIn]

Links:

Volltext

Themen:

Dementia
Depression
Hearing aid
Hearing impairment
Journal Article
Longitudinal
Research Support, Non-U.S. Gov't
Social isolation
Speech-in-noise
UK Biobank

Anmerkungen:

Date Completed 25.04.2022

Date Revised 10.02.2024

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/alz.12416

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM328334499