Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association..
INTRODUCTION: Little is known about the association between speech-in-noise (SiN) hearing impairment and dementia.
METHODS: In 82,039 dementia-free participants aged ≥60 years were selected from the UK Biobank. Cox proportional-hazards models were used to investigate whether SiN hearing impairment is associated with an increased risk of incident dementia.
RESULTS: Over 11 years of follow-up (median = 10.1), 1285 participants developed dementia. Insufficient and poor SiN hearing were associated with a 61% (hazard ratio [HR] = 1.61, 95% confidence [CI] 1.41-1.84) and 91% (HR = 1.91, 95% CI 1.55-2.36) increased risk of developing dementia, respectively, compared to normal SiN hearing. The association remained similar when restricting to follow-up intervals of ≤3, >3 to <6, >6 to <9, and >9 years. There was limited evidence for mediation through depressive symptoms and social isolation.
DISCUSSION: SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
---|---|
Enthalten in: |
Alzheimer's & dementia : the journal of the Alzheimer's Association - 18(2022), 3 vom: 18. März, Seite 445-456 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Stevenson, Jonathan S [VerfasserIn] |
---|
Links: |
---|
Themen: |
Dementia |
---|
Anmerkungen: |
Date Completed 25.04.2022 Date Revised 10.02.2024 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1002/alz.12416 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM328334499 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM328334499 | ||
003 | DE-627 | ||
005 | 20240210232354.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/alz.12416 |2 doi | |
028 | 5 | 2 | |a pubmed24n1286.xml |
035 | |a (DE-627)NLM328334499 | ||
035 | |a (NLM)34288382 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Stevenson, Jonathan S |e verfasserin |4 aut | |
245 | 1 | 0 | |a Speech-in-noise hearing impairment is associated with an increased risk of incident dementia in 82,039 UK Biobank participants |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 25.04.2022 | ||
500 | |a Date Revised 10.02.2024 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. | ||
520 | |a INTRODUCTION: Little is known about the association between speech-in-noise (SiN) hearing impairment and dementia | ||
520 | |a METHODS: In 82,039 dementia-free participants aged ≥60 years were selected from the UK Biobank. Cox proportional-hazards models were used to investigate whether SiN hearing impairment is associated with an increased risk of incident dementia | ||
520 | |a RESULTS: Over 11 years of follow-up (median = 10.1), 1285 participants developed dementia. Insufficient and poor SiN hearing were associated with a 61% (hazard ratio [HR] = 1.61, 95% confidence [CI] 1.41-1.84) and 91% (HR = 1.91, 95% CI 1.55-2.36) increased risk of developing dementia, respectively, compared to normal SiN hearing. The association remained similar when restricting to follow-up intervals of ≤3, >3 to <6, >6 to <9, and >9 years. There was limited evidence for mediation through depressive symptoms and social isolation | ||
520 | |a DISCUSSION: SiN hearing impairment is independently associated with incident dementia, providing further evidence for hearing impairment as a potential modifiable dementia risk factor | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a UK Biobank | |
650 | 4 | |a dementia | |
650 | 4 | |a depression | |
650 | 4 | |a hearing aid | |
650 | 4 | |a hearing impairment | |
650 | 4 | |a longitudinal | |
650 | 4 | |a social isolation | |
650 | 4 | |a speech-in-noise | |
700 | 1 | |a Clifton, Lei |e verfasserin |4 aut | |
700 | 1 | |a Kuźma, Elżbieta |e verfasserin |4 aut | |
700 | 1 | |a Littlejohns, Thomas J |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Alzheimer's & dementia : the journal of the Alzheimer's Association |d 2005 |g 18(2022), 3 vom: 18. März, Seite 445-456 |w (DE-627)NLM168942356 |x 1552-5279 |7 nnns |
773 | 1 | 8 | |g volume:18 |g year:2022 |g number:3 |g day:18 |g month:03 |g pages:445-456 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/alz.12416 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 18 |j 2022 |e 3 |b 18 |c 03 |h 445-456 |