Lineage Contribution of PDGFRα-Expressing Cells in the Developing Mouse Eye
Copyright © 2021 Deyi Zhuo et al..
PDGFRα signaling is critically important in ocular development. Previous data on PDGFRα lacks an expression map with high spatial and temporal resolution and lineage information. In this study, we aim to present a detailed PDGFRα expression and lineage map from early embryogenesis to adulthood. PDGFRα-CreER; mT/mG reporter mice were analyzed. mEGFP-positive cells contributed to multiple ocular lineages in a spatiotemporally regulated manner. A dynamic PDGFRα expression was identified in corneal stromal cells, lens epithelial cells, lens fiber cells, and retinal astrocytes during the entire period of eye development, while PDGFRα expression in retinal astrocytes from E17.5 onwards and in Müller glial cells was identified within two weeks after birth. By revealing detailed characterization of gene expression and function, we present a comprehensive map of PDGFRα-expressing cells in the eye for a better understanding of PDGFRα signaling's role during eye development.
| Errataetall: |
RetractionIn: Biomed Res Int. 2024 Mar 20;2024:9836392. - PMID 38550146 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2021 |
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| Enthalten in: |
BioMed research international - 2021(2021) vom: 01., Seite 4982227 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhuo, Deyi [VerfasserIn] |
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| Links: |
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| Themen: |
EC 2.7.10.1 |
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| Anmerkungen: |
Date Completed 23.09.2021 Date Revised 29.03.2024 published: Electronic-eCollection RetractionIn: Biomed Res Int. 2024 Mar 20;2024:9836392. - PMID 38550146 Citation Status MEDLINE |
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| doi: |
10.1155/2021/4982227 |
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| PPN (Katalog-ID): |
NLM328310204 |
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| 520 | |a Copyright © 2021 Deyi Zhuo et al. | ||
| 520 | |a PDGFRα signaling is critically important in ocular development. Previous data on PDGFRα lacks an expression map with high spatial and temporal resolution and lineage information. In this study, we aim to present a detailed PDGFRα expression and lineage map from early embryogenesis to adulthood. PDGFRα-CreER; mT/mG reporter mice were analyzed. mEGFP-positive cells contributed to multiple ocular lineages in a spatiotemporally regulated manner. A dynamic PDGFRα expression was identified in corneal stromal cells, lens epithelial cells, lens fiber cells, and retinal astrocytes during the entire period of eye development, while PDGFRα expression in retinal astrocytes from E17.5 onwards and in Müller glial cells was identified within two weeks after birth. By revealing detailed characterization of gene expression and function, we present a comprehensive map of PDGFRα-expressing cells in the eye for a better understanding of PDGFRα signaling's role during eye development | ||
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