Pericardial Adipose Tissue Volume and Left Ventricular Assist Device-Associated Outcomes
Copyright © 2021 Elsevier Inc. All rights reserved..
BACKGROUND: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF undergoing left ventricular assist device (LVAD) implantation. This study aimed to evaluate the associations between PAT and LVAD-associated outcomes.
METHODS AND RESULTS: We retrospectively measured computed tomography-derived PAT volumes in 77 consecutive adults who had available chest CT imaging prior to HeartMate 3 LVAD surgery between October 2015 and March 2019 at Duke University Hospital. Study groups were divided into above-median (≥219 cm3) and below-median (<219 cm3) PAT volume. Those with above-median PAT had a higher proportion of atrial fibrillation, chronic kidney disease and ischemic cardiomyopathy. Groups with above-median vs below-median PAT had similar Kaplan-Meier incidence rates over 2 years for (1) composite all-cause mortality, redo-LVAD surgery and cardiac transplantation (35.9 vs 32.2%; log-rank P = 0.65) and (2) composite incident hospitalizations for HF, gastrointestinal bleeding, LVAD-related infection, and stroke (61.5 vs 60.5%; log-rank P = 0.67).
CONCLUSIONS: In patients with end-stage HF undergoing LVAD therapy, PAT is not associated with worse 2-year LVAD-related outcomes. The significance of regional adiposity vs obesity in LVAD patients warrants further investigation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Journal of cardiac failure - 28(2022), 1 vom: 30. Jan., Seite 149-153 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rao, Vishal N [VerfasserIn] |
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| Links: |
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| Themen: |
Clinical outcomes |
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| Anmerkungen: |
Date Completed 28.02.2022 Date Revised 02.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cardfail.2021.06.021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328198846 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Pericardial adipose tissue (PAT) is associated with adverse cardiovascular outcomes in those with and without established heart failure (HF). However, it is not known whether PAT is associated with adverse outcomes in patients with end-stage HF undergoing left ventricular assist device (LVAD) implantation. This study aimed to evaluate the associations between PAT and LVAD-associated outcomes | ||
| 520 | |a METHODS AND RESULTS: We retrospectively measured computed tomography-derived PAT volumes in 77 consecutive adults who had available chest CT imaging prior to HeartMate 3 LVAD surgery between October 2015 and March 2019 at Duke University Hospital. Study groups were divided into above-median (≥219 cm3) and below-median (<219 cm3) PAT volume. Those with above-median PAT had a higher proportion of atrial fibrillation, chronic kidney disease and ischemic cardiomyopathy. Groups with above-median vs below-median PAT had similar Kaplan-Meier incidence rates over 2 years for (1) composite all-cause mortality, redo-LVAD surgery and cardiac transplantation (35.9 vs 32.2%; log-rank P = 0.65) and (2) composite incident hospitalizations for HF, gastrointestinal bleeding, LVAD-related infection, and stroke (61.5 vs 60.5%; log-rank P = 0.67) | ||
| 520 | |a CONCLUSIONS: In patients with end-stage HF undergoing LVAD therapy, PAT is not associated with worse 2-year LVAD-related outcomes. The significance of regional adiposity vs obesity in LVAD patients warrants further investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a LVAD | |
| 650 | 4 | |a MCS | |
| 650 | 4 | |a Regional adiposity | |
| 650 | 4 | |a clinical outcomes | |
| 650 | 4 | |a end-stage heart failure | |
| 650 | 4 | |a left ventricular assist device | |
| 650 | 4 | |a mechanical circulatory support | |
| 650 | 4 | |a pericardial adipose tissue | |
| 700 | 1 | |a Obeid, Mary Jo |e verfasserin |4 aut | |
| 700 | 1 | |a Rigiroli, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Russell, Stuart D |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Chetan B |e verfasserin |4 aut | |
| 700 | 1 | |a Molinger, Jeroen |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Rajan T |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Richa |e verfasserin |4 aut | |
| 700 | 1 | |a Fudim, Marat |e verfasserin |4 aut | |
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