Design and synthesis of analogues of RA-VII-an antitumor bicyclic hexapeptide from Rubiae radix
© 2021. The Author(s)..
The 14-membered cycloisodityrosine is the core structure of RA-series antitumor bicyclic peptides obtained from Rubia plants (Rubiaceae). In this study, an efficient method for the synthesis of cycloisodityrosines from commercially available L-tyrosine derivatives was developed. Using synthetic cycloisodityrosines and cycloisodityrosines with modified structures, several RA-VII analogues were designed and synthesized to explore structure-activity relationships of the cycloisodityrosine moiety of the RA-series peptides, and newly isolated natural peptides were synthesized to establish their structures.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
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| Enthalten in: |
Journal of natural medicines - 75(2021), 4 vom: 09. Sept., Seite 752-761 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hitotsuyanagi, Yukio [VerfasserIn] |
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| Links: |
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| Themen: |
Analogue synthesis |
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| Anmerkungen: |
Date Completed 25.11.2021 Date Revised 18.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11418-021-01542-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM327907428 |
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| 100 | 1 | |a Hitotsuyanagi, Yukio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Design and synthesis of analogues of RA-VII-an antitumor bicyclic hexapeptide from Rubiae radix |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 25.11.2021 | ||
| 500 | |a Date Revised 18.02.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a The 14-membered cycloisodityrosine is the core structure of RA-series antitumor bicyclic peptides obtained from Rubia plants (Rubiaceae). In this study, an efficient method for the synthesis of cycloisodityrosines from commercially available L-tyrosine derivatives was developed. Using synthetic cycloisodityrosines and cycloisodityrosines with modified structures, several RA-VII analogues were designed and synthesized to explore structure-activity relationships of the cycloisodityrosine moiety of the RA-series peptides, and newly isolated natural peptides were synthesized to establish their structures | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Analogue synthesis | |
| 650 | 4 | |a Cyclic peptide | |
| 650 | 4 | |a Cycloisodityrosine | |
| 650 | 4 | |a Cytotoxic activity | |
| 650 | 4 | |a Rubia species | |
| 650 | 4 | |a Rubiaceae | |
| 650 | 7 | |a Peptides, Cyclic |2 NLM | |
| 650 | 7 | |a RA VII |2 NLM | |
| 650 | 7 | |a HVM25O0351 |2 NLM | |
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