Access to highly functionalized imidazolones bearing α-amino acid esters via KOH-promoted annulation of amidines, nitrosoarenes and malonic esters
An efficient approach to obtain highly functionalized imidazolones bearing α-amino acid esters through KOH-mediated one-pot three-component annulation of amidines, nitrosoarenes and malonic esters is reported. This reaction features broad substrate scope, a cheap and readily available promoter, good to high yields for most substrates and mild reaction conditions. The mechanism study shows that the KOH-mediated formation of the imine intermediate via the reaction of nitrosoarenes with malonic esters is a key step.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Organic & biomolecular chemistry - 19(2021), 29 vom: 28. Juli, Seite 6473-6477 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Wenhui [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 08.03.2022 Date Revised 08.03.2022 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d1ob00930c |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM327823445 |
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| 245 | 1 | 0 | |a Access to highly functionalized imidazolones bearing α-amino acid esters via KOH-promoted annulation of amidines, nitrosoarenes and malonic esters |
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| 500 | |a Date Completed 08.03.2022 | ||
| 500 | |a Date Revised 08.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a An efficient approach to obtain highly functionalized imidazolones bearing α-amino acid esters through KOH-mediated one-pot three-component annulation of amidines, nitrosoarenes and malonic esters is reported. This reaction features broad substrate scope, a cheap and readily available promoter, good to high yields for most substrates and mild reaction conditions. The mechanism study shows that the KOH-mediated formation of the imine intermediate via the reaction of nitrosoarenes with malonic esters is a key step | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Xin, Jie |e verfasserin |4 aut | |
| 700 | 1 | |a Zhai, Pingan |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Jianying |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Shuangping |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Wenchao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xing |e verfasserin |4 aut | |
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