Causes of Phenotypic Variability and Disabilities after Prenatal Viral Infections
Prenatal viral infection can lead to a spectrum of neurodevelopmental disabilities or fetal demise. These can include microencephaly, global developmental delay, intellectual disability, refractory epilepsy, deafness, retinal defects, and cortical-visual impairment. Each of these clinical conditions can occur on a semi-quantitative to continuous spectrum, from mild to severe disease, and often as a collective of phenotypes. Such serious outcomes result from viruses' overlapping neuropathology and hosts' common neuronal and gene regulatory response to infections. The etiology of variability in clinical outcomes is not yet clear, but it may be related to viral, host, vector, and/or environmental risk and protective factors that likely interact in multiple ways. In this perspective of the literature, we work toward understanding the causes of phenotypic variability after prenatal viral infections by highlighting key aspects of the viral lifecycle that can affect human disease, with special attention to the 2015 Zika pandemic. Therefore, this work offers important insights into how viral infections and environmental teratogens affect the prenatal brain, toward our ultimate goal of preventing neurodevelopmental disabilities.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
|---|---|
| Enthalten in: |
Tropical medicine and infectious disease - 6(2021), 2 vom: 01. Juni |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kousa, Youssef A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Brain development |
|---|
| Anmerkungen: |
Date Revised 23.07.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.3390/tropicalmed6020095 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM327526300 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM327526300 | ||
| 003 | DE-627 | ||
| 005 | 20231225200958.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/tropicalmed6020095 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1091.xml |
| 035 | |a (DE-627)NLM327526300 | ||
| 035 | |a (NLM)34205913 | ||
| 035 | |a (PII)95 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kousa, Youssef A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Causes of Phenotypic Variability and Disabilities after Prenatal Viral Infections |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 23.07.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Prenatal viral infection can lead to a spectrum of neurodevelopmental disabilities or fetal demise. These can include microencephaly, global developmental delay, intellectual disability, refractory epilepsy, deafness, retinal defects, and cortical-visual impairment. Each of these clinical conditions can occur on a semi-quantitative to continuous spectrum, from mild to severe disease, and often as a collective of phenotypes. Such serious outcomes result from viruses' overlapping neuropathology and hosts' common neuronal and gene regulatory response to infections. The etiology of variability in clinical outcomes is not yet clear, but it may be related to viral, host, vector, and/or environmental risk and protective factors that likely interact in multiple ways. In this perspective of the literature, we work toward understanding the causes of phenotypic variability after prenatal viral infections by highlighting key aspects of the viral lifecycle that can affect human disease, with special attention to the 2015 Zika pandemic. Therefore, this work offers important insights into how viral infections and environmental teratogens affect the prenatal brain, toward our ultimate goal of preventing neurodevelopmental disabilities | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Zika virus | |
| 650 | 4 | |a brain development | |
| 650 | 4 | |a flaviviruses | |
| 650 | 4 | |a global child health | |
| 650 | 4 | |a neurodevelopmental disabilities | |
| 650 | 4 | |a phenotypic variability | |
| 650 | 4 | |a prenatal viral infections | |
| 700 | 1 | |a Hossain, Reafa A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Tropical medicine and infectious disease |d 2016 |g 6(2021), 2 vom: 01. Juni |w (DE-627)NLM275181960 |x 2414-6366 |7 nnns |
| 773 | 1 | 8 | |g volume:6 |g year:2021 |g number:2 |g day:01 |g month:06 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3390/tropicalmed6020095 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 6 |j 2021 |e 2 |b 01 |c 06 | ||