Monte Carlo calculated kilovoltage x-ray arc therapy plans for three lung cancer patients
© 2019 IOP Publishing Ltd..
Purpose: The intent of this work was to evaluate the ability of our 200 kV kilovoltage arc therapy (KVAT) system to treat realistic lung tumors without exceeding dose constraints to organs-at-risk (OAR).Methods and Materials: Monte Carlo (MC) methods and the McO optimization framework generated and inversely optimized KVAT treatment plans for 3 SABR lung cancer patients. The KVAT system was designed to treat deep-seated lesions with kilovoltage photons. KVAT delivers dose to roughly spherical PTVs and therefore non-spherical PTVs were divided into spherical sub-volumes. A prescription dose of 12 Gy/fx × 4 fractions was planned to 90% of the PTV volume. KVAT plans were compared to VMC++ calculated, 6 MV stereotactic ablative radiotherapy (SABR) treatment plans. Dose distributions, dose volume histograms, gradient index (GI), planned mean doses and plan treatment times were calculated. Dose constraints for organs-at-risk (OAR) were taken from RTOG 101.Results: All plans, with the exception of the rib dose calculated in one of the KVAT plans for a peripheral lesion, were within dose-constraints. In general, KVAT plans had higher planned doses to OARs. KVAT GI values were 5.7, 7.2 and 8.9 and SABR values were 4.6, 4.1, and 4.7 for patient 1, 2 and 3, respectively. KVAT plan treatment times were 49, 65 and 17 min for patients 1, 2 and 3, respectively.Conclusions: Inverse optimization and MC methods demonstrated the ability of KVAT to produce treatment plans without exceeding TG 101 dose constraints to OARs for 2 out of 3 investigated lung cancer patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
|---|---|
| Enthalten in: |
Biomedical physics & engineering express - 5(2019), 6 vom: 01. Nov. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Breitkreutz, Dylan Yamabe [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Revised 28.06.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1088/2057-1976/ab4dc5 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM327179694 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM327179694 | ||
| 003 | DE-627 | ||
| 005 | 20231225200213.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1088/2057-1976/ab4dc5 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1090.xml |
| 035 | |a (DE-627)NLM327179694 | ||
| 035 | |a (NLM)34170854 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Breitkreutz, Dylan Yamabe |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Monte Carlo calculated kilovoltage x-ray arc therapy plans for three lung cancer patients |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 28.06.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2019 IOP Publishing Ltd. | ||
| 520 | |a Purpose: The intent of this work was to evaluate the ability of our 200 kV kilovoltage arc therapy (KVAT) system to treat realistic lung tumors without exceeding dose constraints to organs-at-risk (OAR).Methods and Materials: Monte Carlo (MC) methods and the McO optimization framework generated and inversely optimized KVAT treatment plans for 3 SABR lung cancer patients. The KVAT system was designed to treat deep-seated lesions with kilovoltage photons. KVAT delivers dose to roughly spherical PTVs and therefore non-spherical PTVs were divided into spherical sub-volumes. A prescription dose of 12 Gy/fx × 4 fractions was planned to 90% of the PTV volume. KVAT plans were compared to VMC++ calculated, 6 MV stereotactic ablative radiotherapy (SABR) treatment plans. Dose distributions, dose volume histograms, gradient index (GI), planned mean doses and plan treatment times were calculated. Dose constraints for organs-at-risk (OAR) were taken from RTOG 101.Results: All plans, with the exception of the rib dose calculated in one of the KVAT plans for a peripheral lesion, were within dose-constraints. In general, KVAT plans had higher planned doses to OARs. KVAT GI values were 5.7, 7.2 and 8.9 and SABR values were 4.6, 4.1, and 4.7 for patient 1, 2 and 3, respectively. KVAT plan treatment times were 49, 65 and 17 min for patients 1, 2 and 3, respectively.Conclusions: Inverse optimization and MC methods demonstrated the ability of KVAT to produce treatment plans without exceeding TG 101 dose constraints to OARs for 2 out of 3 investigated lung cancer patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Monte Carlo | |
| 650 | 4 | |a kilovoltage | |
| 650 | 4 | |a lung cancer | |
| 650 | 4 | |a radiation therapy | |
| 700 | 1 | |a Renaud, Marc-Andre |e verfasserin |4 aut | |
| 700 | 1 | |a Weil, Michael David |e verfasserin |4 aut | |
| 700 | 1 | |a Zavgorodni, Sergei |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Jaeyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Baxter, Henry |e verfasserin |4 aut | |
| 700 | 1 | |a Seuntjens, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Boyd, Douglas |e verfasserin |4 aut | |
| 700 | 1 | |a Bazalova-Carter, Magdalena |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomedical physics & engineering express |d 2015 |g 5(2019), 6 vom: 01. Nov. |w (DE-627)NLM257937595 |x 2057-1976 |7 nnns |
| 773 | 1 | 8 | |g volume:5 |g year:2019 |g number:6 |g day:01 |g month:11 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1088/2057-1976/ab4dc5 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 5 |j 2019 |e 6 |b 01 |c 11 | ||