Learning and memory disorders related to hippocampal inflammation following exposure to air pollution

© Springer Nature Switzerland AG 2021..

It has been demonstrated that sub-chronic exposure to air pollution containing nanoscale (˂100 nm) diesel exhaust particles (DEPs) may lead to excessive oxidative stress and neuro-inflammation in adult male mice. Hereby, we investigated the effects of DEPs on hippocampus-dependent spatial learning and neuro-inflammation and memory-related gene expression in male mice. In this study, we divided 48 adult NMRI male mice into control group VS. three exposure groups. Mice were exposed to 300-350 μg/m3 DEPs for 2, 5, and 7 h daily for 12 weeks. The Morris Water Maze (MWM) and Elevated Plus Maze device were used to examine anxiety, spatial memory and learning, respectively. The mRNAs expression of pro-inflammatory cytokines, N-methyl-D-aspartate (NMDA) receptor subunits, and glutaminase were studied in hippocampus (HI) by real-time RT-PCR. Besides, malondialdehyde (MDA) tests were used to determine the state of oxidative stress. After 5 and 7 h. of DEPs exposure, mRNA expression of NR2A and NR3B IL1α, IL1β, TNFα, NMDA receptor subunits and MDA levels increased significantly (P < 0.05). Also, DEPs exposed mice for 2, 5, and 7 h. showed diminished entrance into open arms with short time spent there. Indeed, 5 and 7 h/day exposed mice required a longer time to reach the hidden platform. Sub-chronic exposure to DEPs increased oxidative stress markers, neuroinflammation, anxiety, impaired spatial learning and memory.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:19

Enthalten in:

Journal of environmental health science & engineering - 19(2021), 1 vom: 07. Juni, Seite 261-272

Sprache:

Englisch

Beteiligte Personen:

Ehsanifar, Mojtaba [VerfasserIn]
Jafari, Ahmad Jonidi [VerfasserIn]
Montazeri, Zeinab [VerfasserIn]
Kalantari, Roshanak Rezaei [VerfasserIn]
Gholami, Mitra [VerfasserIn]
Ashtarinezhad, Azadeh [VerfasserIn]

Links:

Volltext

Themen:

Air pollution
Diesel exhaust particles
Journal Article
Learning and memory
Nanotoxicology
Neuroinflammation

Anmerkungen:

Date Revised 23.01.2022

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.1007/s40201-020-00600-x

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM326976876