Learning and memory disorders related to hippocampal inflammation following exposure to air pollution
© Springer Nature Switzerland AG 2021..
It has been demonstrated that sub-chronic exposure to air pollution containing nanoscale (˂100 nm) diesel exhaust particles (DEPs) may lead to excessive oxidative stress and neuro-inflammation in adult male mice. Hereby, we investigated the effects of DEPs on hippocampus-dependent spatial learning and neuro-inflammation and memory-related gene expression in male mice. In this study, we divided 48 adult NMRI male mice into control group VS. three exposure groups. Mice were exposed to 300-350 μg/m3 DEPs for 2, 5, and 7 h daily for 12 weeks. The Morris Water Maze (MWM) and Elevated Plus Maze device were used to examine anxiety, spatial memory and learning, respectively. The mRNAs expression of pro-inflammatory cytokines, N-methyl-D-aspartate (NMDA) receptor subunits, and glutaminase were studied in hippocampus (HI) by real-time RT-PCR. Besides, malondialdehyde (MDA) tests were used to determine the state of oxidative stress. After 5 and 7 h. of DEPs exposure, mRNA expression of NR2A and NR3B IL1α, IL1β, TNFα, NMDA receptor subunits and MDA levels increased significantly (P < 0.05). Also, DEPs exposed mice for 2, 5, and 7 h. showed diminished entrance into open arms with short time spent there. Indeed, 5 and 7 h/day exposed mice required a longer time to reach the hidden platform. Sub-chronic exposure to DEPs increased oxidative stress markers, neuroinflammation, anxiety, impaired spatial learning and memory.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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Enthalten in: |
Journal of environmental health science & engineering - 19(2021), 1 vom: 07. Juni, Seite 261-272 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ehsanifar, Mojtaba [VerfasserIn] |
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Links: |
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Themen: |
Air pollution |
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Anmerkungen: |
Date Revised 23.01.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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doi: |
10.1007/s40201-020-00600-x |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM326976876 |
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520 | |a It has been demonstrated that sub-chronic exposure to air pollution containing nanoscale (˂100 nm) diesel exhaust particles (DEPs) may lead to excessive oxidative stress and neuro-inflammation in adult male mice. Hereby, we investigated the effects of DEPs on hippocampus-dependent spatial learning and neuro-inflammation and memory-related gene expression in male mice. In this study, we divided 48 adult NMRI male mice into control group VS. three exposure groups. Mice were exposed to 300-350 μg/m3 DEPs for 2, 5, and 7 h daily for 12 weeks. The Morris Water Maze (MWM) and Elevated Plus Maze device were used to examine anxiety, spatial memory and learning, respectively. The mRNAs expression of pro-inflammatory cytokines, N-methyl-D-aspartate (NMDA) receptor subunits, and glutaminase were studied in hippocampus (HI) by real-time RT-PCR. Besides, malondialdehyde (MDA) tests were used to determine the state of oxidative stress. After 5 and 7 h. of DEPs exposure, mRNA expression of NR2A and NR3B IL1α, IL1β, TNFα, NMDA receptor subunits and MDA levels increased significantly (P < 0.05). Also, DEPs exposed mice for 2, 5, and 7 h. showed diminished entrance into open arms with short time spent there. Indeed, 5 and 7 h/day exposed mice required a longer time to reach the hidden platform. Sub-chronic exposure to DEPs increased oxidative stress markers, neuroinflammation, anxiety, impaired spatial learning and memory | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Air pollution | |
650 | 4 | |a Diesel exhaust particles | |
650 | 4 | |a Learning and memory | |
650 | 4 | |a Nanotoxicology | |
650 | 4 | |a Neuroinflammation | |
700 | 1 | |a Jafari, Ahmad Jonidi |e verfasserin |4 aut | |
700 | 1 | |a Montazeri, Zeinab |e verfasserin |4 aut | |
700 | 1 | |a Kalantari, Roshanak Rezaei |e verfasserin |4 aut | |
700 | 1 | |a Gholami, Mitra |e verfasserin |4 aut | |
700 | 1 | |a Ashtarinezhad, Azadeh |e verfasserin |4 aut | |
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