Clinical Efficacy of Ponatinib in Philadelphia-Positive T-Cell Acute Lymphoblastic Leukemia with Extramedullary Involvement
© 2021 S. Karger AG, Basel..
T-cell acute lymphoblastic leukemia (T-ALL) is a rare entity in the adult acute leukemia setting. Translocation (9;22)(q34;q11) and BCR-ABL1 rearrangement are occasionally found in T-ALL and have been reported in no more than 100 cases in the literature (most of which are chronic myeloid leukemia blast crisis). Here, we report the remarkable effectiveness of third-generation tyrosine-kinase inhibitor ponatinib in obtaining hematological and metabolic remission, in a patient with Philadelphia chromosome-positive de novo T-ALL and outcomes of a therapeutic strategy containing chemotherapy intensification, nelarabine, and allogeneic hematopoietic stem cell transplantation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:144 |
|---|---|
| Enthalten in: |
Acta haematologica - 144(2021), 6 vom: 11., Seite 688-692 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cristiano, Gianluca [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
4340891KFS |
|---|
| Anmerkungen: |
Date Completed 06.12.2021 Date Revised 14.12.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1159/000516003 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM326779507 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM326779507 | ||
| 003 | DE-627 | ||
| 005 | 20231225195332.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000516003 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1089.xml |
| 035 | |a (DE-627)NLM326779507 | ||
| 035 | |a (NLM)34130278 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cristiano, Gianluca |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical Efficacy of Ponatinib in Philadelphia-Positive T-Cell Acute Lymphoblastic Leukemia with Extramedullary Involvement |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.12.2021 | ||
| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 S. Karger AG, Basel. | ||
| 520 | |a T-cell acute lymphoblastic leukemia (T-ALL) is a rare entity in the adult acute leukemia setting. Translocation (9;22)(q34;q11) and BCR-ABL1 rearrangement are occasionally found in T-ALL and have been reported in no more than 100 cases in the literature (most of which are chronic myeloid leukemia blast crisis). Here, we report the remarkable effectiveness of third-generation tyrosine-kinase inhibitor ponatinib in obtaining hematological and metabolic remission, in a patient with Philadelphia chromosome-positive de novo T-ALL and outcomes of a therapeutic strategy containing chemotherapy intensification, nelarabine, and allogeneic hematopoietic stem cell transplantation | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Philadelphia chromosome | |
| 650 | 4 | |a Ponatinib | |
| 650 | 4 | |a T-cell acute lymphoblastic leukemia | |
| 650 | 7 | |a Imidazoles |2 NLM | |
| 650 | 7 | |a Protein Kinase Inhibitors |2 NLM | |
| 650 | 7 | |a Pyridazines |2 NLM | |
| 650 | 7 | |a ponatinib |2 NLM | |
| 650 | 7 | |a 4340891KFS |2 NLM | |
| 650 | 7 | |a Fusion Proteins, bcr-abl |2 NLM | |
| 650 | 7 | |a EC 2.7.10.2 |2 NLM | |
| 700 | 1 | |a Nanni, Jacopo |e verfasserin |4 aut | |
| 700 | 1 | |a Sartor, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Parisi, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Marconi, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Barbato, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Arpinati, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Bonifazi, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Curti, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Cavo, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Paolini, Stefania |e verfasserin |4 aut | |
| 700 | 1 | |a Papayannidis, Cristina |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta haematologica |d 1948 |g 144(2021), 6 vom: 11., Seite 688-692 |w (DE-627)NLM000152889 |x 1421-9662 |7 nnns |
| 773 | 1 | 8 | |g volume:144 |g year:2021 |g number:6 |g day:11 |g pages:688-692 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1159/000516003 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 144 |j 2021 |e 6 |b 11 |h 688-692 | ||