Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

© 2021 Caiado et al..

Inflammation is an evolutionarily selected defense response to infection or tissue damage that involves activation and consumption of immune cells in order to reestablish and maintain organismal integrity. In this process, hematopoietic stem cells (HSCs) are themselves exposed to inflammatory cues and via proliferation and differentiation, replace mature immune cells in a demand-adapted fashion. Here, we review how major sources of systemic inflammation act on and subsequently shape HSC fate and function. We highlight how lifelong inflammatory exposure contributes to HSC inflamm-aging and selection of premalignant HSC clones. Finally, we explore emerging areas of interest and open questions remaining in the field.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:218

Enthalten in:

The Journal of experimental medicine - 218(2021), 7 vom: 05. Juli

Sprache:

Englisch

Beteiligte Personen:

Caiado, Francisco [VerfasserIn]
Pietras, Eric M [VerfasserIn]
Manz, Markus G [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Anmerkungen:

Date Completed 12.10.2021

Date Revised 07.01.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1084/jem.20201541

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM326767177