Social functioning and brain imaging in individuals at clinical high-risk for psychosis : A systematic review

Copyright © 2021 Elsevier B.V. All rights reserved..

Impairments in social functioning are a core impairment in psychosis and are associated with poor outcomes. These deficits are found in those at clinical high-risk (CHR) for psychosis, and can persist even in the absence of transition. However, the neurobiological underpinnings of social functioning remain unclear, therefore we conducted a systematic review of brain metrics that have been associated with social functioning in youth at CHR for psychosis. Five databases (MEDLINE, CINAHL, EBM reviews, Embase, and PsycINFO) were searched from inception to May 5, 2020. Studies were selected if they examined brain imaging, and social functioning in youth at CHR for psychosis. Of the 9629 citations found through online database searching, 12 studies with 696 CHR participants met inclusion criteria. Too few studies were focused on the same brain region using the same methodology to perform a meta-analysis, however, loci within the prefrontal cortex were most often associated with social functioning. Few studies have linked social functioning to brain imaging metrics, suggesting that future work should focus on this relationship.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:233

Enthalten in:

Schizophrenia research - 233(2021) vom: 15. Juli, Seite 3-12

Sprache:

Englisch

Beteiligte Personen:

Metzak, Paul D [VerfasserIn]
Farris, Megan S [VerfasserIn]
Placsko, Thea [VerfasserIn]
Braun, Amy [VerfasserIn]
Bonneville, Dominique [VerfasserIn]
Brummitt, Kali [VerfasserIn]
Chu, Monica [VerfasserIn]
Addington, Jean [VerfasserIn]

Links:

Volltext

Themen:

Clinical high risk
Imaging
Journal Article
Psychosis
Research Support, N.I.H., Extramural
Social functioning
Systematic Review
Systematic review

Anmerkungen:

Date Completed 19.10.2021

Date Revised 16.07.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.schres.2021.04.013

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM32674407X