Interobserver variability in target volume delineation in definitive radiotherapy for thoracic esophageal cancer : a multi-center study from China
PURPOSE: To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring consistency as much as possible to lay the foundation for multi-center prospective studies.
METHODS: Sixteen cancer centers throughout China participated in this study. In Phase 1, three suitable cases with upper, middle, and lower TEC were chosen, and participants were asked to contour a group of gross tumor volume (GTV-T), nodal gross tumor volume (GTV-N) and clinical target volume (CTV) for each case based on their routine experience. In Phase 2, the same clinicians were instructed to follow a contouring protocol to re-contour another group of target volume. The variation of the target volume was analyzed and quantified using dice similarity coefficient (DSC).
RESULTS: Sixteen clinicians provided routine volumes, whereas ten provided both routine and protocol volumes for each case. The IOV of routine GTV-N was the most striking in all cases, with the smallest DSC of 0.37 (95% CI 0.32-0.42), followed by CTV, whereas GTV-T showed high consistency. After following the protocol, the smallest DSC of GTV-N was improved to 0.64 (95% CI 0.45-0.83, P = 0.005) but the DSC of GTV-T and CTV remained constant in most cases.
CONCLUSION: Variability in target volume delineation was observed, but it could be significantly reduced and controlled using mandatory interventions.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
|---|---|
| Enthalten in: |
Radiation oncology (London, England) - 16(2021), 1 vom: 09. Juni, Seite 102 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Chang, Xiao [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cancer of the esophagus |
|---|
| Anmerkungen: |
Date Completed 06.12.2021 Date Revised 14.12.2021 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1186/s13014-020-01691-4 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM326560203 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM326560203 | ||
| 003 | DE-627 | ||
| 005 | 20231225194847.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13014-020-01691-4 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1088.xml |
| 035 | |a (DE-627)NLM326560203 | ||
| 035 | |a (NLM)34107984 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Chang, Xiao |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Interobserver variability in target volume delineation in definitive radiotherapy for thoracic esophageal cancer |b a multi-center study from China |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.12.2021 | ||
| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring consistency as much as possible to lay the foundation for multi-center prospective studies | ||
| 520 | |a METHODS: Sixteen cancer centers throughout China participated in this study. In Phase 1, three suitable cases with upper, middle, and lower TEC were chosen, and participants were asked to contour a group of gross tumor volume (GTV-T), nodal gross tumor volume (GTV-N) and clinical target volume (CTV) for each case based on their routine experience. In Phase 2, the same clinicians were instructed to follow a contouring protocol to re-contour another group of target volume. The variation of the target volume was analyzed and quantified using dice similarity coefficient (DSC) | ||
| 520 | |a RESULTS: Sixteen clinicians provided routine volumes, whereas ten provided both routine and protocol volumes for each case. The IOV of routine GTV-N was the most striking in all cases, with the smallest DSC of 0.37 (95% CI 0.32-0.42), followed by CTV, whereas GTV-T showed high consistency. After following the protocol, the smallest DSC of GTV-N was improved to 0.64 (95% CI 0.45-0.83, P = 0.005) but the DSC of GTV-T and CTV remained constant in most cases | ||
| 520 | |a CONCLUSION: Variability in target volume delineation was observed, but it could be significantly reduced and controlled using mandatory interventions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Cancer of the esophagus | |
| 650 | 4 | |a Interobserver variability | |
| 650 | 4 | |a Radiation therapy | |
| 650 | 4 | |a Target volume delineation | |
| 700 | 1 | |a Deng, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Zongmei |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Wenling |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Miaoling |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Xiaolu |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Kaixian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Yonggang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ke |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yidian |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Huitao |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Zhilong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jihong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Lihua |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Xueying |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Shuchai |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Ruohui |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Junqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Cairong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Fuquan |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Xiaorong |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Qingsong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wencheng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Gaofeng |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Hailei |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Xinchen |e verfasserin |4 aut | |
| 700 | 1 | |a Ge, Xiaolin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Caihong |e verfasserin |4 aut | |
| 700 | 1 | |a Ge, Hong |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Dingjie |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yadi |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Na |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Xianshu |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Shangbin |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xiao, Zefen |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Radiation oncology (London, England) |d 2006 |g 16(2021), 1 vom: 09. Juni, Seite 102 |w (DE-627)NLM163016356 |x 1748-717X |7 nnns |
| 773 | 1 | 8 | |g volume:16 |g year:2021 |g number:1 |g day:09 |g month:06 |g pages:102 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s13014-020-01691-4 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 16 |j 2021 |e 1 |b 09 |c 06 |h 102 | ||