Cancer stem cell-immune cell crosstalk in tumour progression

© 2021. Springer Nature Limited..

Cellular heterogeneity and an immunosuppressive tumour microenvironment are independent yet synergistic drivers of tumour progression and underlie therapeutic resistance. Recent studies have highlighted the complex interaction between these cell-intrinsic and cell-extrinsic mechanisms. The reciprocal communication between cancer stem cells (CSCs) and infiltrating immune cell populations in the tumour microenvironment is a paradigm for these interactions. In this Perspective, we discuss the signalling programmes that simultaneously induce CSCs and reprogramme the immune response to facilitate tumour immune evasion, metastasis and recurrence. We further highlight biological factors that can impact the nature of CSC-immune cell communication. Finally, we discuss targeting opportunities for simultaneous regulation of the CSC niche and immunosurveillance.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:21

Enthalten in:

Nature reviews. Cancer - 21(2021), 8 vom: 08. Aug., Seite 526-536

Sprache:

Englisch

Beteiligte Personen:

Bayik, Defne [VerfasserIn]
Lathia, Justin D [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Anmerkungen:

Date Completed 23.09.2021

Date Revised 03.02.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1038/s41568-021-00366-w

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM326518045