Cancer stem cell-immune cell crosstalk in tumour progression
© 2021. Springer Nature Limited..
Cellular heterogeneity and an immunosuppressive tumour microenvironment are independent yet synergistic drivers of tumour progression and underlie therapeutic resistance. Recent studies have highlighted the complex interaction between these cell-intrinsic and cell-extrinsic mechanisms. The reciprocal communication between cancer stem cells (CSCs) and infiltrating immune cell populations in the tumour microenvironment is a paradigm for these interactions. In this Perspective, we discuss the signalling programmes that simultaneously induce CSCs and reprogramme the immune response to facilitate tumour immune evasion, metastasis and recurrence. We further highlight biological factors that can impact the nature of CSC-immune cell communication. Finally, we discuss targeting opportunities for simultaneous regulation of the CSC niche and immunosurveillance.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
---|---|
Enthalten in: |
Nature reviews. Cancer - 21(2021), 8 vom: 08. Aug., Seite 526-536 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Bayik, Defne [VerfasserIn] |
---|
Links: |
---|
Themen: |
Journal Article |
---|
Anmerkungen: |
Date Completed 23.09.2021 Date Revised 03.02.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1038/s41568-021-00366-w |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM326518045 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM326518045 | ||
003 | DE-627 | ||
005 | 20231225194754.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1038/s41568-021-00366-w |2 doi | |
028 | 5 | 2 | |a pubmed24n1088.xml |
035 | |a (DE-627)NLM326518045 | ||
035 | |a (NLM)34103704 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Bayik, Defne |e verfasserin |4 aut | |
245 | 1 | 0 | |a Cancer stem cell-immune cell crosstalk in tumour progression |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 23.09.2021 | ||
500 | |a Date Revised 03.02.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2021. Springer Nature Limited. | ||
520 | |a Cellular heterogeneity and an immunosuppressive tumour microenvironment are independent yet synergistic drivers of tumour progression and underlie therapeutic resistance. Recent studies have highlighted the complex interaction between these cell-intrinsic and cell-extrinsic mechanisms. The reciprocal communication between cancer stem cells (CSCs) and infiltrating immune cell populations in the tumour microenvironment is a paradigm for these interactions. In this Perspective, we discuss the signalling programmes that simultaneously induce CSCs and reprogramme the immune response to facilitate tumour immune evasion, metastasis and recurrence. We further highlight biological factors that can impact the nature of CSC-immune cell communication. Finally, we discuss targeting opportunities for simultaneous regulation of the CSC niche and immunosurveillance | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Review | |
700 | 1 | |a Lathia, Justin D |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Nature reviews. Cancer |d 2001 |g 21(2021), 8 vom: 08. Aug., Seite 526-536 |w (DE-627)NLM117837857 |x 1474-1768 |7 nnns |
773 | 1 | 8 | |g volume:21 |g year:2021 |g number:8 |g day:08 |g month:08 |g pages:526-536 |
856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41568-021-00366-w |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 21 |j 2021 |e 8 |b 08 |c 08 |h 526-536 |