Copper-Catalyzed Three-Component Alkene Carbofunctionalization : C-N, C-O, and C-C Bond Formation from a Single Reaction Platform
A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented, including carboetherification, carboesterification, carboarylation, and carboamination. The scope of the reaction is presented with respect to the carbon electrophile, the olefin, and the nucleophile. Furthermore, the synthesis of γ-lactams via a carboamination reaction is demonstrated in a telescoped three-step protocol.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Organic letters - 23(2021), 12 vom: 18. Juni, Seite 4538-4542 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Buchanan, Travis L [VerfasserIn] |
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| Links: |
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| Themen: |
7440-44-0 |
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| Anmerkungen: |
Date Completed 15.11.2021 Date Revised 03.01.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acs.orglett.1c01180 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326449493 |
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| 100 | 1 | |a Buchanan, Travis L |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Copper-Catalyzed Three-Component Alkene Carbofunctionalization |b C-N, C-O, and C-C Bond Formation from a Single Reaction Platform |
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| 500 | |a Date Revised 03.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented, including carboetherification, carboesterification, carboarylation, and carboamination. The scope of the reaction is presented with respect to the carbon electrophile, the olefin, and the nucleophile. Furthermore, the synthesis of γ-lactams via a carboamination reaction is demonstrated in a telescoped three-step protocol | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Alkenes |2 NLM | |
| 650 | 7 | |a Lactams |2 NLM | |
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| 650 | 7 | |a Copper |2 NLM | |
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| 700 | 1 | |a Gockel, Samuel N |e verfasserin |4 aut | |
| 700 | 1 | |a Veatch, Alexander M |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ya-Nong |e verfasserin |4 aut | |
| 700 | 1 | |a Hull, Kami L |e verfasserin |4 aut | |
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| 856 | 4 | 0 | |u http://dx.doi.org/10.1021/acs.orglett.1c01180 |3 Volltext |
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