Metabolic engineering tools for Saccharomyces cerevisiae
Since its birth in the early 1990s, metabolic engineering technology has gone 30 years rapid development. As one of the preferred chassis for metabolic engineering, S. cerevisiae cells have been engineered into microbial cell factories for the production of a variety of bulk chemicals and novel high value-added bioactive compounds. In recent years, synthetic biology, bioinformatics, machine learning and other technologies have also greatly contributed to the technological development and applications of metabolic engineering. This review summarizes the important technological development for metabolic engineering of S. cerevisiae in the past 30 years. Firstly, classical metabolic engineering tools and strategies were reviewed, followed by reviewing systems metabolic engineering and synthetic biology driven metabolic engineering approaches. The review is concluded with discussing future perspectives for metabolic engineering of S. cerevisiae in the light of state-of-the-art technological development.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 37(2021), 5 vom: 25. Mai, Seite 1578-1602 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Jiang, Lihong [VerfasserIn] |
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| Links: |
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| Themen: |
Genome evolution |
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| Anmerkungen: |
Date Completed 07.06.2021 Date Revised 07.06.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.13345/j.cjb.200690 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM326337679 |
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| 520 | |a Since its birth in the early 1990s, metabolic engineering technology has gone 30 years rapid development. As one of the preferred chassis for metabolic engineering, S. cerevisiae cells have been engineered into microbial cell factories for the production of a variety of bulk chemicals and novel high value-added bioactive compounds. In recent years, synthetic biology, bioinformatics, machine learning and other technologies have also greatly contributed to the technological development and applications of metabolic engineering. This review summarizes the important technological development for metabolic engineering of S. cerevisiae in the past 30 years. Firstly, classical metabolic engineering tools and strategies were reviewed, followed by reviewing systems metabolic engineering and synthetic biology driven metabolic engineering approaches. The review is concluded with discussing future perspectives for metabolic engineering of S. cerevisiae in the light of state-of-the-art technological development | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
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| 650 | 4 | |a genome evolution | |
| 650 | 4 | |a metabolic engineering | |
| 650 | 4 | |a synthetic biology | |
| 650 | 4 | |a systems biology | |
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| 700 | 1 | |a Huang, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Zhinan |e verfasserin |4 aut | |
| 700 | 1 | |a Lian, Jiazhang |e verfasserin |4 aut | |
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